Hauke B. Werner, et.al., A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system., Glia, 2013, 61

http://rdf.ncbi.nlm.nih.gov/pubmed/23322581

Hauke B. Werner, et.al., A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system., Glia, 2013, 61

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gpm6b<tm1Kan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5487806

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal motor capabilities/coordination/movement_Gpm6b<tm1Kan>/Gpm6b<+>,Plp1<tm1Kan>/Plp1<tm1Kan>
  http://metadb.riken.jp/0002066I129S1Sv129X1SvJC57BL6JGpm6btm1KanGpm6bPlp1tm1KanPlp1tm1KanPlp1tm1KanGpm6bGpm6btm1Kan
• decreased anterior commissure size_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0008226I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• neuron degeneration_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0003224I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal oligodendrocyte morphology_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0000953I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal oligodendrocyte apoptosis_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0010205I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal glial cell morphology_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0003634I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal myelination_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0000920I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal axon morphology_Gpm6b<tm1Kan>/Y
  http://metadb.riken.jp/0005404I129S1Sv129X1SvJC57BL6JGpm6btm1KanYGpm6btm1Kan
• muscle hypertonia_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0004143I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• astrocytosis_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0003354I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal myelin sheath morphology_Gpm6b<tm1Kan>/Y
  http://metadb.riken.jp/0003871I129S1Sv129X1SvJC57BL6JGpm6btm1KanYGpm6btm1Kan
• axon degeneration_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0005405I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• demyelination_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0000921I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• premature death_Gpm6b<tm1Kan>/Gpm6b<+>,Plp1<tm1Kan>/Plp1<tm1Kan>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JGpm6btm1KanGpm6bPlp1tm1KanPlp1tm1KanPlp1tm1KanGpm6bGpm6btm1Kan
• premature death_Gpm6b<tm1Kan>/Gpm6b<tm1Kan>,Plp1<tm1Kan>/Plp1<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JGpm6btm1KanGpm6btm1KanPlp1tm1KanPlp1Plp1tm1KanGpm6btm1KanPlp1
• impaired hearing_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0006325I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• enlarged brain ventricles_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0011380I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• tremors_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0000745I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• absent visual evoked potential_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0010749I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• microgliosis_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0008918I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal stationary movement_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0001388I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal myelin sheath morphology_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0003871I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal myelin sheath morphology_Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0003871I129S1Sv129X1SvJPlp1tm1KanYPlp1tm1Kan
• ataxia_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0001393I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• retinal degeneration_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0001326I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• muscle spasm_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0000743I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal motor coordination/ balance_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0001516I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal motor capabilities/coordination/movement_Gpm6b<tm1Kan>/Gpm6b<tm1Kan>,Plp1<tm1Kan>/Plp1<+>
  http://metadb.riken.jp/0002066I129S1Sv129X1SvJC57BL6JGpm6btm1KanGpm6btm1KanPlp1tm1KanPlp1Plp1tm1KanGpm6btm1KanPlp1
• premature death_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• decreased cholesterol level_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0003983I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• increased apoptosis_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0006042I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal axon morphology_Gpm6b<tm1Kan>/Gpm6b<tm1Kan>
  http://metadb.riken.jp/0005404I129S1Sv129X1SvJC57BL6JGpm6btm1KanGpm6btm1KanGpm6btm1Kan
• hunched posture_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0001505I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal brain white matter morphology_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0008026I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• decreased cholesterol level_Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0003983I129S1Sv129X1SvJPlp1tm1KanYPlp1tm1Kan
• abnormal auditory brainstem response waveform shape_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0011966I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan
• abnormal myelin sheath morphology_Gpm6b<tm1Kan>/Gpm6b<tm1Kan>
  http://metadb.riken.jp/0003871I129S1Sv129X1SvJC57BL6JGpm6btm1KanGpm6btm1KanGpm6btm1Kan
• decreased corpus callosum size_Gpm6b<tm1Kan> Plp1<tm1Kan>/Y
  http://metadb.riken.jp/0000781I129S1Sv129X1SvJC57BL6JGpm6btm1KanPlp1tm1KanYGpm6btm1KanPlp1tm1Kan

class

http://purl.org/net/cito/citesAsAuthority

• Gpm6b<tm1Kan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5487806