Camille. Lobry, et.al., Notch pathway activation targets AML-initiating cell homeostasis and differentiation., The Journal of experimental medicine, 2013, 210

http://rdf.ncbi.nlm.nih.gov/pubmed/23359070

Camille. Lobry, et.al., Notch pathway activation targets AML-initiating cell homeostasis and differentiation., The Journal of experimental medicine, 2013, 210

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5496402
• Gt(ROSA)26Sor<tm1Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5496396

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5496402
• Gt(ROSA)26Sor<tm1Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5496396

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal bone marrow cell physiology_Gt(ROSA)26Sor<tm2Iaai>/Gt(ROSA)26Sor<+>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0009278I129SSvEvC57BL6GtROSA26Sortm2IaaiGtROSA26SorTgUBCcreERT21Ejb0TgUBCcreERT21EjbGtROSA26SorGtROSA26Sortm2Iaai
• enlarged spleen_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000691I129Ncstntm11AkliNcstntm11AkliTgVav1cre1Graf0TgVav1cre1GrafNcstntm11Akli
• abnormal bone marrow cell physiology_Eef1a1<tm2Arge>/Eef1a1<+>,Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009278IC57BL6C57BL6NTacEef1a1tm2ArgeEef1a1GtROSA26Sortm9creESR1ArteGtROSA26SorGtROSA26Sortm9creESR1ArteEef1a1GtROSA26SorEef1a1tm2Arge
• abnormal common myeloid progenitor cell morphology_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0006410I129SSvEvC57BL6Ncstntm11AkliNcstntm11AkliTet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiNcstntm11AkliTgVav1cre1Graf
• abnormal bone marrow cell physiology_Gt(ROSA)26Sor<tm1Iaai>/Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>
  http://metadb.riken.jp/0009278IC57BL6C57BL6NTacGtROSA26Sortm1IaaiGtROSA26Sortm9creESR1ArteGtROSA26Sortm1IaaiGtROSA26Sortm9creESR1Arte
• increased leukemia incidence_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0002026I129SSvEvC57BL6Ncstntm11AkliNcstntm11AkliTet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiNcstntm11AkliTgVav1cre1Graf
• myeloid hyperplasia_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0010373I129SSvEvC57BL6Ncstntm11AkliNcstntm11AkliTet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiNcstntm11AkliTgVav1cre1Graf
• abnormal bone marrow cell physiology_Gt(ROSA)26Sor<tm1Iaai>/Gt(ROSA)26Sor<+>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0009278I129SSvEvC57BL6GtROSA26Sortm1IaaiGtROSA26SorTgUBCcreERT21Ejb0TgUBCcreERT21EjbGtROSA26SorGtROSA26Sortm1Iaai
• increased leukocyte cell number_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000218I129SSvEvC57BL6Ncstntm11AkliNcstntm11AkliTet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiNcstntm11AkliTgVav1cre1Graf
• premature death_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0002083I129SSvEvC57BL6Ncstntm11AkliNcstntm11AkliTet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiNcstntm11AkliTgVav1cre1Graf
• premature death_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0002083I129Ncstntm11AkliNcstntm11AkliTgVav1cre1Graf0TgVav1cre1GrafNcstntm11Akli
• abnormal splenocyte physiology_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0009333I129Ncstntm11AkliNcstntm11AkliTgVav1cre1Graf0TgVav1cre1GrafNcstntm11Akli
• altered tumor pathology_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0010639I129SSvEvC57BL6Ncstntm11AkliNcstntm11AkliTet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiNcstntm11AkliTgVav1cre1Graf
• enlarged spleen_Ncstn<tm1.1Akli>/Ncstn<tm1.1Akli>,Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000691I129SSvEvC57BL6Ncstntm11AkliNcstntm11AkliTet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiNcstntm11AkliTgVav1cre1Graf