Holly J. Garringer, et.al., Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice., PloS one, 2013, 8

http://rdf.ncbi.nlm.nih.gov/pubmed/23418567

Holly J. Garringer, et.al., Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice., PloS one, 2013, 8

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/db/mgi_rdf/MGI:5525087

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hunched posture_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001505IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• increased inflammatory response_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001846IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• dystonia_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0005323IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• abnormal synapse morphology_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0009538IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• abnormal synapse morphology_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0009538IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• amyloid beta deposits_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0003329IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• weight loss_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0001263IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• premature death_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0002083IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• hunched posture_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0001505IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• premature death_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0002083IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• short stride length_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0001407IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• neurodegeneration_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0002229IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• weight loss_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001263IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• tau protein deposits_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0004250IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• abnormal gait_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0001406IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• abnormal grooming behavior_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001440IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• limb grasping_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0001513IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• abnormal synapse morphology_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0009538IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• abnormal grooming behavior_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0001440IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• limb grasping_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001513IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• hunched posture_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001505IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• limb grasping_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001513IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• tau protein deposits_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0004250IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• neurofibrillary tangles_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0003214IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• abnormal gait_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001406IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• abnormal neurite morphology_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0008415IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi
• weight loss_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi,Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001263IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpITM2B1RuviTgPrnpMAPTP301LRuvi
• abnormal grooming behavior_Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/0001440IC3HeBFeJC57BL6TgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuviTgPrnpMAPTP301LRuvi
• abnormal astrocyte morphology_Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
  http://metadb.riken.jp/0002182IC3HeBFeJC57BL6TgPrnpITM2B1RuviTgPrnpITM2B1RuviTgPrnpITM2B1Ruvi

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-MAPT*P301L)#Ruvi
  http://metadb.riken.jp/db/mgi_rdf/MGI:5525087