Paolo. Sportoletti, et.al., The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model., Blood, 2013, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/23435463

Paolo. Sportoletti, et.al., The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model., Blood, 2013, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5502770

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5502770

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• thrombocytopenia_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003179IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26Sortm1CAGNPM1GenoTgMx1cre1Cgn0TgMx1cre1CgnGtROSA26Sortm1CAGNPM1Geno
• abnormal platelet morphology_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004720IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26Sortm1CAGNPM1GenoTgMx1cre1Cgn0TgMx1cre1CgnGtROSA26Sortm1CAGNPM1Geno
• enlarged spleen_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26SorTgMx1cre1Cgn0GtROSA26Sortm1CAGNPM1GenoTgMx1cre1CgnGtROSA26Sor
• abnormal megakaryocyte differentiation_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000229IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26SorTgMx1cre1Cgn0GtROSA26Sortm1CAGNPM1GenoTgMx1cre1CgnGtROSA26Sor
• myeloid hyperplasia_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010373IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26SorTgMx1cre1Cgn0GtROSA26Sortm1CAGNPM1GenoTgMx1cre1CgnGtROSA26Sor
• thrombocytopenia_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003179IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26SorTgMx1cre1Cgn0GtROSA26Sortm1CAGNPM1GenoTgMx1cre1CgnGtROSA26Sor
• abnormal megakaryocyte differentiation_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000229IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26Sortm1CAGNPM1GenoTgMx1cre1Cgn0TgMx1cre1CgnGtROSA26Sortm1CAGNPM1Geno
• increased megakaryocyte cell number_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008254IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26SorTgMx1cre1Cgn0GtROSA26Sortm1CAGNPM1GenoTgMx1cre1CgnGtROSA26Sor
• increased megakaryocyte cell number_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008254IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26Sortm1CAGNPM1GenoTgMx1cre1Cgn0TgMx1cre1CgnGtROSA26Sortm1CAGNPM1Geno
• abnormal platelet morphology_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004720IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26SorTgMx1cre1Cgn0GtROSA26Sortm1CAGNPM1GenoTgMx1cre1CgnGtROSA26Sor
• enlarged spleen_Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691IC57BL6CBAGtROSA26Sortm1CAGNPM1GenoGtROSA26Sortm1CAGNPM1GenoTgMx1cre1Cgn0TgMx1cre1CgnGtROSA26Sortm1CAGNPM1Geno