Michio. Nakaya, et.al., GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance., Nature communications, 2013, 4

http://rdf.ncbi.nlm.nih.gov/pubmed/23443560

Michio. Nakaya, et.al., GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance., Nature communications, 2013, 4

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased CD8-positive, alpha-beta T cell number_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0008079B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• glomerulonephritis_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0002743B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• decreased CD8-positive, naive alpha-beta T cell number_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0013435B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased spleen weight_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0004952B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• enlarged spleen_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0000691B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased memory T cell number_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0008049B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased anti-double stranded DNA antibody level_Mfge8<tm1Osa>/Mfge8<tm1Osa>
  http://metadb.riken.jp/0004762I129S1Sv129X1SvJC57BL6Mfge8tm1OsaMfge8tm1OsaMfge8tm1Osa
• impaired macrophage phagocytosis_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0001798B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• abnormal T cell subpopulation ratio_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0003944B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased spleen iron level_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0008809B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased IgG level_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0002493B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased spleen white pulp amount_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0008478B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased anti-double stranded DNA antibody level_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0004762B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• abnormal glomerular mesangium morphology_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0011339B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca
• increased splenocyte number_Grk6<tm1.1Mca>/Grk6<tm1.1Mca>
  http://metadb.riken.jp/0009338B6129S4Grk6tm11McaGrk6tm11McaGrk6tm11McaGrk6tm11Mca

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased anti-double stranded DNA antibody level in RBRC01726
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1011261