Steven Andrew. Baker, et.al., An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders., Cell, 2013, 152

http://rdf.ncbi.nlm.nih.gov/pubmed/23452848

Steven Andrew. Baker, et.al., An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders., Cell, 2013, 152

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(MECP2*R270X/GFP)#Hzo
  http://metadb.riken.jp/db/mgi_rdf/MGI:5491036
• Tg(MECP2*G273X/GFP)#Hzo
  http://metadb.riken.jp/db/mgi_rdf/MGI:5491039

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal gait_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001406I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• abnormal hippocampus morphology_Mecp2<tm1.1Bird>/Mecp2<+>
  http://metadb.riken.jp/0000807I129P2OlaHsdMecp2tm11BirdMecp2Mecp2tm11BirdMecp2
• disheveled coat_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0001511I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• increased body weight_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001260I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• increased body weight_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0001260I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• decreased brain weight_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0002175I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• abnormal cerebral cortex morphology_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0000788I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• premature death_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0002083I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• abnormal brain development_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0000913I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• decreased brain weight_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0002175I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• tremors_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0000745I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• abnormal gait_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0001406I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• decreased brain weight_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0002175I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• no abnormal phenotype detected_Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0002169I129P2OlaHsdFVBTgMECP2G273XGFPHzo0TgMECP2G273XGFPHzo
• abnormal hippocampus morphology_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0000807I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• increased body weight_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0001260I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• premature death_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0002083I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• disheveled coat_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001511I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• abnormal hippocampus morphology_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0000807I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• tremors_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0000745I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• abnormal brain development_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0000913I129P2OlaHsdFVBMecp2tm11BirdYMecp2tm11Bird
• abnormal cerebral cortex morphology_Mecp2<tm1.1Bird>/Mecp2<+>
  http://metadb.riken.jp/0000788I129P2OlaHsdMecp2tm11BirdMecp2Mecp2tm11BirdMecp2
• abnormal cerebral cortex morphology_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0000788I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• abnormal cerebral cortex morphology_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0000788I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• abnormal gait_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0001406I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• tremors_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0000745I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• abnormal hippocampus morphology_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0000807I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• abnormal brain development_Mecp2<tm1.1Bird>/Y,Tg(MECP2*G273X/GFP)#Hzo/0
  http://metadb.riken.jp/0000913I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2G273XGFPHzo0Mecp2tm11BirdTgMECP2G273XGFPHzo
• premature death_Mecp2<tm1.1Bird>/Y,Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0002083I129P2OlaHsdFVBMecp2tm11BirdYTgMECP2R270XGFPHzo0Mecp2tm11BirdTgMECP2R270XGFPHzo
• no abnormal phenotype detected_Tg(MECP2*R270X/GFP)#Hzo/0
  http://metadb.riken.jp/0002169I129P2OlaHsdFVBTgMECP2R270XGFPHzo0TgMECP2R270XGFPHzo

class

http://purl.org/net/cito/citesAsAuthority

• Tg(MECP2*R270X/GFP)#Hzo
  http://metadb.riken.jp/db/mgi_rdf/MGI:5491036
• Tg(MECP2*G273X/GFP)#Hzo
  http://metadb.riken.jp/db/mgi_rdf/MGI:5491039