Toshikatsu. Hanada, et.al., CLP1 links tRNA metabolism to progressive motor-neuron loss., Nature, 2013, 495

http://rdf.ncbi.nlm.nih.gov/pubmed/23474986

Toshikatsu. Hanada, et.al., CLP1 links tRNA metabolism to progressive motor-neuron loss., Nature, 2013, 495

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Clp1<tm1.1Pngr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5554792
• Tg(Mnx1-Clp1,-EGFP)#Pngr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5554793
• Clp1<tm2.1Pngr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5555842
• Clp1<tm2.2Pngr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5554923

class

http://purl.org/net/cito/citesAsAuthority

• Clp1<tm1.1Pngr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5554792
• Tg(Mnx1-Clp1,-EGFP)#Pngr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5554793
• Clp1<tm2.1Pngr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5555842
• Clp1<tm2.2Pngr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5554923

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• respiratory failure_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001953B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• impaired balance_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001525CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• ataxia_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001393CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• motor neuron degeneration_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0000938B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• skeletal muscle atrophy_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0009417CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• oxidative stress_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0003674I129P2OlaHsdC57BL6JClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• abnormal neuromuscular synapse morphology_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001053B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• lordosis_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0000162B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• decreased motor neuron number_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>,Tg(Hlxb9-GFP)1Tmj/0
  http://metadb.riken.jp/0000939I129P2OlaHsdC57BL6C57BL6JCBAClp1tm11PngrClp1tm11PngrTgHlxb9GFP1Tmj0Clp1tm11PngrTgHlxb9GFP1Tmj
• increased cellular sensitivity to oxidative stress_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0008412I129P2OlaHsdC57BL6JClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• embryonic lethality, complete penetrance_Clp1<tm2.2Pngr>/Clp1<tm2.2Pngr>
  http://metadb.riken.jp/0011092I129P2OlaHsdC57BL6JClp1tm22PngrClp1tm22PngrClp1tm22Pngr
• abnormal gait_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001406CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• progressive muscle weakness_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0000748CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• abnormal axon morphology_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0005404CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• premature death_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0002083CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• decreased birth weight_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0009674B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• decreased motor neuron number_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0000939CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• hyporesponsive to tactile stimuli_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0005498B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• paralysis_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0000753CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• abnormal motor coordination/ balance_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001516CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• axon degeneration_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0005405CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• lethality, complete penetrance_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0011400CCgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• abnormal neuromuscular synapse morphology_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001053CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• abnormal sciatic nerve morphology_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0002651CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• abnormal phrenic nerve innervation pattern to diaphragm_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0012055B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• abnormal cell physiology_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0005621I129P2OlaHsdC57BL6JClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• increased tumor incidence_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002020I129P2OlaHsd129S2SvPasC57BL6C57BL6JClp1tm11PngrClp1tm11PngrTrp53tm1TyjTrp53tm1TyjClp1tm11PngrTrp53tm1Tyj
• maternal effect_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0003718CBACgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• decreased motor neuron number_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0000939B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• defasiculated phrenic nerve_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0001080B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr
• neonatal lethality, complete penetrance_Clp1<tm1.1Pngr>/Clp1<tm1.1Pngr>
  http://metadb.riken.jp/0011087B6CgClp1tm11PngrClp1tm11PngrClp1tm11PngrClp1tm11Pngr