Anthony J. Mutsaers, et.al., Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA., Bone, 2013, 55

http://rdf.ncbi.nlm.nih.gov/pubmed/23486187

Anthony J. Mutsaers, et.al., Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA., Bone, 2013, 55

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased osteosarcoma incidence_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003789I129P2OlaHsdC57BL6CD1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgSp7tTAtetOEGFPcre1Amc
• increased metastatic potential_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
  http://metadb.riken.jp/0001272IC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0TgtetORNAiTrp53ASlowe0TgtetORNAiTrp53ASloweRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc
• increased metastatic potential_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001272I129P2OlaHsdC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased metastatic potential_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
  http://metadb.riken.jp/0001272IC57BL6CD1TgSp7tTAtetOEGFPcre1Amc0TgtetORNAiTrp53ASlowe0TgtetORNAiTrp53ASloweTgSp7tTAtetOEGFPcre1Amc
• increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003789I129P2OlaHsdC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• premature death_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
  http://metadb.riken.jp/0002083IC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0TgtetORNAiTrp53ASlowe0TgtetORNAiTrp53ASloweRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc
• premature death_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• increased osteosarcoma incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
  http://metadb.riken.jp/0003789IC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0TgtetORNAiTrp53ASlowe0TgtetORNAiTrp53ASloweRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc
• premature death_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
  http://metadb.riken.jp/0002083IC57BL6CD1TgSp7tTAtetOEGFPcre1Amc0TgtetORNAiTrp53ASlowe0TgtetORNAiTrp53ASloweTgSp7tTAtetOEGFPcre1Amc
• increased metastatic potential_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001272I129P2OlaHsdC57BL6CD1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgSp7tTAtetOEGFPcre1Amc
• increased osteosarcoma incidence_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
  http://metadb.riken.jp/0003789IC57BL6CD1TgSp7tTAtetOEGFPcre1Amc0TgtetORNAiTrp53ASlowe0TgtetORNAiTrp53ASloweTgSp7tTAtetOEGFPcre1Amc
• increased circulating alkaline phosphatase level_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
  http://metadb.riken.jp/0002968IC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0TgtetORNAiTrp53ASlowe0TgtetORNAiTrp53ASloweRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc
• increased hibernoma incidence_Rb1<tm3Tyj>/Rb1<tm3Tyj>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0010344I129P2OlaHsdC57BL6CD1Rb1tm3TyjRb1tm3TyjTgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnRb1tm3TyjTgSp7tTAtetOEGFPcre1AmcTrp53tm1Brn
• premature death_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CD1TgSp7tTAtetOEGFPcre1Amc0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgSp7tTAtetOEGFPcre1Amc