W. Hanel, et.al., Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis., Cell death and differentiation, 2013, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/23538418

W. Hanel, et.al., Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis., Cell death and differentiation, 2013, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm2.1Umol>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5708410
• Trp53<tm1.1Umol>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5708402

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased cellular sensitivity to gamma-irradiation_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0003207I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased reproductive system tumor incidence_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0010287I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• premature death_Trp53<tm2.1Umol>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6C57BL6NTacTrp53tm21UmolTrp53tm21UmolTrp53tm21Umol
• increased carcinoma incidence_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002038I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• decreased tumor latency_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0010308I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased B cell derived lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002023I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• increased T cell derived lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002024I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• increased B cell derived lymphoma incidence_Trp53<tm1.1Umol>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002023I129S6SvEvTacC57BL6C57BL6NTacTrp53tm11UmolTrp53tm11UmolTrp53tm11Umol
• abnormal mesenchyme morphology_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0006301I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased sarcoma incidence_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002032I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• premature death_Trp53<tm1.1Umol>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6C57BL6NTacTrp53tm11UmolTrp53tm11UmolTrp53tm11Umol
• increased B cell derived lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002023I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased T cell derived lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002024I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0012431I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0012431I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• increased B cell derived lymphoma incidence_Trp53<tm2.1Umol>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002023I129S6SvEvTacC57BL6C57BL6NTacTrp53tm21UmolTrp53tm21UmolTrp53tm21Umol
• premature death_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002083I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• premature death_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002083I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased leukemia incidence_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002026I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased carcinoma incidence_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002038I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• increased hematopoietic stem cell number_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0004809I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• decreased tumor latency_Trp53<tm1.1Umol>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0010308I129S6SvEvTacC57BL6C57BL6NTacTrp53tm11UmolTrp53tm11UmolTrp53tm11Umol
• increased reproductive system tumor incidence_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0010287I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• increased hematopoietic stem cell number_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0004809I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol
• increased T cell derived lymphoma incidence_Trp53<tm2.1Umol>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0002024I129S6SvEvTacC57BL6C57BL6NTacTrp53tm21UmolTrp53tm21UmolTrp53tm21Umol
• increased T cell derived lymphoma incidence_Trp53<tm1.1Umol>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002024I129S6SvEvTacC57BL6C57BL6NTacTrp53tm11UmolTrp53tm11UmolTrp53tm11Umol
• decreased cellular sensitivity to gamma-irradiation_Trp53<tm1Tyj>/Trp53<tm2.1Umol>
  http://metadb.riken.jp/0003207I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm21UmolTrp53tm1TyjTrp53tm21Umol
• increased sarcoma incidence_Trp53<tm1Tyj>/Trp53<tm1.1Umol>
  http://metadb.riken.jp/0002032I129S2SvPas129S6SvEvTacC57BL6C57BL6NTacTrp53tm1TyjTrp53tm11UmolTrp53tm1TyjTrp53tm11Umol

class

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm2.1Umol>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5708410
• Trp53<tm1.1Umol>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5708402