Antoine. Reginensi, et.al., Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development., PLoS genetics, 2013, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/23555292

Antoine. Reginensi, et.al., Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development., PLoS genetics, 2013, 9

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Wwtr1<tm1Hmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5486299
• Yap1<tm1Hmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5486298

class

http://purl.org/net/cito/citesAsAuthority

• Wwtr1<tm1Hmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5486299
• Yap1<tm1Hmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5486298

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal kidney medulla morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003014I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal loop of Henle morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004755I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney papilla morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004193I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney development_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000527I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• decreased renal glomerulus number_Wasl<tm2Sbs>/Wasl<tm2Sbs>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004505I129C57BL6JWasltm2SbsWasltm2SbsSix2tm1tTAtetOEGFPcreAmcSix2Six2Wasltm2SbsSix2tm1tTAtetOEGFPcreAmc
• decreased renal glomerulus number_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004505I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• anuria_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003624I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• decreased renal tubule number_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000524I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• decreased renal tubule number_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000524I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• impaired branching involved in ureteric bud morphogenesis_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004936I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney papilla morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004193I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• renal hypoplasia_Wasl<tm2Sbs>/Wasl<tm2Sbs>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003446I129C57BL6JWasltm2SbsWasltm2SbsSix2tm1tTAtetOEGFPcreAmcSix2Six2Wasltm2SbsSix2tm1tTAtetOEGFPcreAmc
• decreased renal glomerulus number_Wwtr1<tm1Hmc>/Wwtr1<tm1Hmc>,Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004505I129129S1Sv129S6SvEvTac129X1SvJC57BL6JC57BL6NCrlWwtr1tm1HmcWwtr1tm1HmcYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Six2tm1tTAtetOEGFPcreAmcSix2Wwtr1tm1HmcYap1tm1Hmc
• decreased renal tubule number_Wasl<tm2Sbs>/Wasl<tm2Sbs>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000524I129C57BL6JWasltm2SbsWasltm2SbsSix2tm1tTAtetOEGFPcreAmcSix2Six2Wasltm2SbsSix2tm1tTAtetOEGFPcreAmc
• decreased renal glomerulus number_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004505I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney development_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000527I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• anuria_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003624I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney development_Wwtr1<tm1Hmc>/Wwtr1<tm1Hmc>,Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000527I129129S1Sv129S6SvEvTac129X1SvJC57BL6JC57BL6NCrlWwtr1tm1HmcWwtr1tm1HmcYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Six2tm1tTAtetOEGFPcreAmcSix2Wwtr1tm1HmcYap1tm1Hmc
• kidney cysts_Wwtr1<tm1Hmc>/Wwtr1<tm1Hmc>,Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003675I129129S1Sv129S6SvEvTac129X1SvJC57BL6JC57BL6NCrlWwtr1tm1HmcWwtr1tm1HmcYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Six2tm1tTAtetOEGFPcreAmcSix2Wwtr1tm1HmcYap1tm1Hmc
• postnatal lethality, complete penetrance_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011085I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• renal hypoplasia_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003446I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• podocyte foot process effacement_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0008140I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal nephrogenic zone morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011334I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• kidney cysts_Wwtr1<tm1Hmc>/Wwtr1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003675I129129S1Sv129X1SvJC57BL6JWwtr1tm1HmcWwtr1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Wwtr1tm1HmcSix2Six2tm1tTAtetOEGFPcreAmc
• kidney hemorrhage_Wwtr1<tm1Hmc>/Wwtr1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000533I129129S1Sv129X1SvJC57BL6JWwtr1tm1HmcWwtr1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Wwtr1tm1HmcSix2Six2tm1tTAtetOEGFPcreAmc
• decreased renal tubule number_Wwtr1<tm1Hmc>/Wwtr1<tm1Hmc>,Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000524I129129S1Sv129S6SvEvTac129X1SvJC57BL6JC57BL6NCrlWwtr1tm1HmcWwtr1tm1HmcYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Six2tm1tTAtetOEGFPcreAmcSix2Wwtr1tm1HmcYap1tm1Hmc
• abnormal proximal convoluted tubule morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004756I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney cortex morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000521I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal proximal convoluted tubule morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004756I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal renal tubule morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0002703I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal nephrogenic zone morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011334I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• postnatal lethality, complete penetrance_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011085I129C57BL6JCdc42tm1BrakCdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2Cdc42tm1BrakSix2tm1tTAtetOEGFPcreAmcSix2
• renal hypoplasia_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0003446I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal metanephros morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011364I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal renal glomerulus morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0005325I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney cortex morphology_Yap1<tm1Hmc>/Yap1<tm1Hmc>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000521I129129S6SvEvTacC57BL6JC57BL6NCrlYap1tm1HmcYap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2Yap1tm1HmcSix2tm1tTAtetOEGFPcreAmcSix2