Ognian C. Ikonomov, et.al., Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching., American journal of physiology. Endocrinology and metabolism, 2013, 305

http://rdf.ncbi.nlm.nih.gov/pubmed/23673157

Ognian C. Ikonomov, et.al., Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching., American journal of physiology. Endocrinology and metabolism, 2013, 305

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased total body fat amount_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0010024IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• increased body weight_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0001260IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• increased adipocyte glucose uptake_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0030016IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• decreased muscle cell glucose uptake_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0030022IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• decreased heart weight_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0002834IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• no abnormal phenotype detected_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>
  http://metadb.riken.jp/0002169IC57BL6Pikfyvetm11AshiPikfyvetm11AshiPikfyvetm11Ashi
• increased fat cell size_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0006094IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• increased renal fat pad weight_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0009302IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• impaired glucose tolerance_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0005293IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• increased circulating triglyceride level_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0001552IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• increased susceptibility to age related obesity_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0003212IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• increased circulating insulin level_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0002079IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• increased gonadal fat pad weight_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0009285IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte
• insulin resistance_Pikfyve<tm1.1Ashi>/Pikfyve<tm1.1Ashi>,Tg(Ckm-cre)28Arte/0
  http://metadb.riken.jp/0005331IC57BL6Pikfyvetm11AshiPikfyvetm11AshiTgCkmcre28Arte0Pikfyvetm11AshiTgCkmcre28Arte