Christopher R. Dowdy, et.al., A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation., Experimental hematology, 2013, 41

http://rdf.ncbi.nlm.nih.gov/pubmed/23823022

Christopher R. Dowdy, et.al., A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation., Experimental hematology, 2013, 41

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Runx1<tm2.1Gss>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5613812

class

http://purl.org/net/cito/citesAsAuthority

• Runx1<tm2.1Gss>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5613812

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal megakaryocyte differentiation_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0000229I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased macrophage cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0005425I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• abnormal erythropoiesis_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0000245I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• enlarged spleen_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0000691I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased granulocyte number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0000322I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• myeloid hyperplasia_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0010373I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• anemia_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0001577I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• decreased pre-pro B cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0011816I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased red blood cell distribution width_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0010067I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• abnormal erythroid progenitor cell morphology_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0008801I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• decreased hematocrit_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0000208I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased mature B cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0008210I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• decreased mean corpuscular volume_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0002591I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• abnormal definitive hematopoiesis_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0002123I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• thrombocytosis_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0005505I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• decreased CD8-positive, alpha-beta T cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0008079I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• abnormal leukocyte morphology_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0008246I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased pro-B cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0008186I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• decreased immature B cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0008215I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• abnormal megakaryocyte morphology_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0002417I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased monocyte cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0000220I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased mean platelet volume_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0002599I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased hemoglobin content_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0005564I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• abnormal erythrocyte morphology_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0002447I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• abnormal spleen white pulp morphology_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0002357I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss
• increased erythrocyte cell number_Runx1<tm2.1Gss>/Runx1<tm2.1Gss>
  http://metadb.riken.jp/0003131I129S4SvJaeC57BL6Runx1tm21GssRunx1tm21GssRunx1tm21Gss