Suzana. Gispert, et.al., Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors., Human molecular genetics, 2013, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/23851121

Suzana. Gispert, et.al., Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors., Human molecular genetics, 2013, 22

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal T cell activation_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001828IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal cellular respiration_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0010954IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• female infertility_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001926IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased startle reflex_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001489IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• small testis_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001147IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased cell proliferation_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0000352IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• hypoactivity_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001402IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• azoospermia_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0005159IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• premature death_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0002083IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased susceptibility to weight gain_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0010182IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• hypoactivity_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001402IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal seminiferous tubule epithelium morphology_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0011750IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• small ovary_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001127IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased corpora lutea number_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0002680IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• increased granulosa cell apoptosis_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0013508IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• arrest of spermatogenesis_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001155IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• male infertility_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001925IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• arrest of spermatogenesis_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001155IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• female infertility_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001926IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• increased embryonic tissue cell apoptosis_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0013504IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal granulosa cell morphology_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0008868IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• decreased cell proliferation_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0000352IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal cellular respiration_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0010954IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• premature death_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0002083IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• decreased body length_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001258IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• disorganized mitochondrial cristae_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0011636IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal granulosa cell morphology_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0008868IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased startle reflex_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001489IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• abnormal T cell activation_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001828IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased vertical activity_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0002757IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal oogenesis_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001931IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• abnormal oogenesis_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001931IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• decreased corpora lutea number_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0002680IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• abnormal mitochondrial chromosome morphology_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0011638IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal seminiferous tubule epithelium morphology_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0011750IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• increased mitochondria size_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0011630IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• disorganized mitochondrial cristae_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0011636IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• early cellular replicative senescence_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0008008IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• small ovary_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001127IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• dermatitis_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001194IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• dermatitis_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001194IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• small testis_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001147IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• abnormal mitochondrial chromosome morphology_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0011638IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased vertical activity_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0002757IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• increased mitochondria size_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0011630IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• male infertility_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0001925IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• decreased body length_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0001258IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• azoospermia_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0005159IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• preweaning lethality, incomplete penetrance_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0011110IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• decreased susceptibility to weight gain_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0010182IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm
• preweaning lethality, incomplete penetrance_Clpp<Gt(IST11134F10)Tigm>/Clpp<Gt(IST11134F10)Tigm>
  http://metadb.riken.jp/0011110IC57BL6NClppGtIST11134F10TigmClppGtIST11134F10TigmClppGtIST11134F10Tigm
• early cellular replicative senescence_Clpp<Gt(IST13563G11)Tigm>/Clpp<Gt(IST13563G11)Tigm>
  http://metadb.riken.jp/0008008IC57BL6NClppGtIST13563G11TigmClppGtIST13563G11TigmClppGtIST13563G11Tigm