Lois. Kelsey, et.al., ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice., PLoS genetics, 2013, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/23874215

Lois. Kelsey, et.al., ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice., PLoS genetics, 2013, 9

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Klf3<m1Cmhd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567987

class

http://purl.org/net/cito/citesAsAuthority

• Klf3<m1Cmhd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567987

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• atrial septal defect_Klf3<m1Cmhd>/Klf3<m1Cmhd>
  http://metadb.riken.jp/0010403IC3HHeJC57BL6JKlf3m1CmhdKlf3m1CmhdKlf3m1Cmhd
• increased liver weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• hypotension_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0001596IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• congestive heart failure_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0006138IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased brain weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0002176I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• decreased percent body fat/body weight_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0005459IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased leukocyte cell number_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0000218I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• decreased systemic arterial blood pressure_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002843IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased mean systemic arterial blood pressure_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0004876I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased heart weight_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002833IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• aortic valve stenosis_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0006117I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• increased atrioventricular cushion size_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0003808IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased abdominal fat pad weight_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0009287IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• abnormal interventricular septum morphology_Klf3<m1Cmhd>/Klf3<m1Cmhd>
  http://metadb.riken.jp/0000281IC3HHeJC57BL6JKlf3m1CmhdKlf3m1CmhdKlf3m1Cmhd
• lethality throughout fetal growth and development, incomplete penetrance_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0011109IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased body weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0001262I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• decreased body weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0001262I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• abnormal heart right atrium morphology_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0003922I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• abnormal heart left atrium morphology_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0003923I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased red blood cell distribution width_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0010067I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased brain weight_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002176IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• preweaning lethality, incomplete penetrance_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0011110I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• abnormal blood flow velocity_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0000233IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• thick aortic valve cusps_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0010593I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• increased kidney weight_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0003917IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• enlarged heart right atrium_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0008727IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• lethality throughout fetal growth and development, complete penetrance_Klf3<m1Cmhd>/Klf3<m1Cmhd>
  http://metadb.riken.jp/0011099IC3HHeJC57BL6JKlf3m1CmhdKlf3m1CmhdKlf3m1Cmhd
• increased kidney weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0003917I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• bicuspid aortic valve_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0010484IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased body weight_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0001262IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• abnormal heart right atrium morphology_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0003922IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• reticulocytosis_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0002640I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• increased lung weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0005630I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• abnormal aortic valve morphology_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002747IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• tricuspid valve regurgitation_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0006044I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• increased spleen weight_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0004952IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• abnormal blood flow velocity_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0000233I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased brain weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0002176I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• reticulocytosis_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002640IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased oxygen consumption_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0005289IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased erythrocyte cell number_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002875IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased heart weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0002833I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• increased cardiac muscle contractility_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0005599IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• hematoma_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0008817IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased lung weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0005630I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• thick aortic valve cusps_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0010593IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased heart right ventricle size_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0010563I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• increased cardiac output_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0003394I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• premature death_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002083IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased liver weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased kidney weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0003917I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• abnormal blood flow velocity_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0000233IBALBcJC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3Klf3m1Cmhd
• atrial septal defect_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0010403IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• abnormal aorta morphology_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0000272IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased mean systemic arterial blood pressure_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0004876IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• reticulocytosis_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0002640I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• decreased abdominal fat pad weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0009287I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• abnormal heart left ventricle morphology_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0003921IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• hypervolemia_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0010127IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased abdominal fat pad weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0009287I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• abnormal ventricle myocardium morphology_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0010499IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• enlarged heart left atrium_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0008726IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• cardiac hypertrophy_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0001625IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• abnormal heart left ventricle morphology_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0003921I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• abnormal heart right atrium morphology_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0003922I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• increased heart right ventricle size_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0010563I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased leukocyte cell number_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0000218I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• anemia_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0001577IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• abnormal blood pressure regulation_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0010695IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased cardiac output_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0003394IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• pulmonary valve regurgitation_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0006048I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased red blood cell distribution width_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0010067I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• ventricular septal defect_Klf3<m1Cmhd>/Klf3<m1Cmhd>
  http://metadb.riken.jp/0010402IC3HHeJC57BL6JKlf3m1CmhdKlf3m1CmhdKlf3m1Cmhd
• increased spleen weight_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0004952I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• tricuspid valve regurgitation_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0006044I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• neonatal lethality, incomplete penetrance_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0011088IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• increased heart weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0002833I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• aortic valve stenosis_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0006117IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• decreased hemoglobin content_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0002874IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3
• pulmonary valve regurgitation_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0006048I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• preweaning lethality, incomplete penetrance_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0011110I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased spleen weight_Klf3<Gt(CH0516)Wtsi>/Klf3<Gt(CH0516)Wtsi>
  http://metadb.riken.jp/0004952I129P2OlaHsdC57BL6Klf3GtCH0516WtsiKlf3GtCH0516WtsiKlf3GtCH0516Wtsi
• increased cardiac output_Klf3<Gt(XS0187)Wtsi>/Klf3<Gt(XS0187)Wtsi>
  http://metadb.riken.jp/0003394I129P2OlaHsdC57BL6Klf3GtXS0187WtsiKlf3GtXS0187WtsiKlf3GtXS0187Wtsi
• abnormal ventricle myocardium morphology_Klf3<m1Cmhd>/Klf3<m1Cmhd>
  http://metadb.riken.jp/0010499IC3HHeJC57BL6JKlf3m1CmhdKlf3m1CmhdKlf3m1Cmhd
• abnormal heart left atrium morphology_Klf3<m1Cmhd>/Klf3<+>
  http://metadb.riken.jp/0003923IC3HHeJC57BL6JKlf3m1CmhdKlf3Klf3m1CmhdKlf3