Inai. Park, et.al., Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation., The Journal of cell biology, 2013, 202

http://rdf.ncbi.nlm.nih.gov/pubmed/23878276

Inai. Park, et.al., Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation., The Journal of cell biology, 2013, 202

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Bub1b<tm1.1Hsl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5543300

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased sarcoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0002032I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased lung adenocarcinoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0002027I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased rectum adenocarcinoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0009315I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased adenocarcinoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0009308I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• enlarged spleen_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0000691I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased lymphoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0012431I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• abnormal embryo development_Bub1b<tm1.1Hsl>/Bub1b<tm1.1Hsl>
  http://metadb.riken.jp/0001672I129C57BL6Bub1btm11HslBub1btm11HslBub1btm11Hsl
• increased hepatocellular carcinoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0003331I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• abnormal mitosis_Bub1b<tm1.1Hsl>/Bub1b<+>,Tg(HIST1H2BB/EGFP)1Pa/0
  http://metadb.riken.jp/0004046I129S1Sv129X1SvJC57BL6Bub1btm11HslBub1bTgHIST1H2BBEGFP1Pa0Bub1bBub1btm11HslTgHIST1H2BBEGFP1Pa
• abnormal mitotic spindle assembly checkpoint_Bub1b<tm1.1Hsl>/Bub1b<+>,Tg(HIST1H2BB/EGFP)1Pa/0
  http://metadb.riken.jp/0009762I129S1Sv129X1SvJC57BL6Bub1btm11HslBub1bTgHIST1H2BBEGFP1Pa0Bub1bBub1btm11HslTgHIST1H2BBEGFP1Pa
• increased hemangiosarcoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0003667I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased leukemia incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0002026I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• abnormal cell nucleus morphology_Bub1b<tm1.1Hsl>/Bub1b<+>,Tg(HIST1H2BB/EGFP)1Pa/0
  http://metadb.riken.jp/0003111I129S1Sv129X1SvJC57BL6Bub1btm11HslBub1bTgHIST1H2BBEGFP1Pa0Bub1bBub1btm11HslTgHIST1H2BBEGFP1Pa
• embryonic lethality between implantation and somite formation, complete penetrance_Bub1b<tm1.1Hsl>/Bub1b<tm1.1Hsl>
  http://metadb.riken.jp/0011096I129C57BL6Bub1btm11HslBub1btm11HslBub1btm11Hsl
• increased fibrosarcoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0010363I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased apoptosis_Bub1b<tm1.1Hsl>/Bub1b<tm1.1Hsl>
  http://metadb.riken.jp/0006042I129C57BL6Bub1btm11HslBub1btm11HslBub1btm11Hsl
• increased B cell derived lymphoma incidence_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0002023I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• embryonic growth retardation_Bub1b<tm1.1Hsl>/Bub1b<tm1.1Hsl>
  http://metadb.riken.jp/0003984I129C57BL6Bub1btm11HslBub1btm11HslBub1btm11Hsl
• aneuploidy_Bub1b<tm1.1Hsl>/Bub1b<+>,Tg(HIST1H2BB/EGFP)1Pa/0
  http://metadb.riken.jp/0004024I129S1Sv129X1SvJC57BL6Bub1btm11HslBub1bTgHIST1H2BBEGFP1Pa0Bub1bBub1btm11HslTgHIST1H2BBEGFP1Pa
• increased incidence of induced tumors_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0002021I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased B cell proliferation_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0005154I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b
• increased spleen white pulp amount_Bub1b<tm1.1Hsl>/Bub1b<+>
  http://metadb.riken.jp/0008478I129C57BL6Bub1btm11HslBub1bBub1btm11HslBub1b

class

http://purl.org/net/cito/citesAsAuthority

• Bub1b<tm1.1Hsl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5543300