Christie M. Buchovecky, et.al., A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome., Nature genetics, 2013, 45

http://rdf.ncbi.nlm.nih.gov/pubmed/23892605

Christie M. Buchovecky, et.al., A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome., Nature genetics, 2013, 45

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sum1<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489912
• Sum2<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489913
• Sqle<Sum3-Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489914
• Sum4<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489915
• Sum5<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489916

class

http://purl.org/net/cito/citesAsAuthority

• Sum1<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489912
• Sum2<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489913
• Sqle<Sum3-Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489914
• Sum4<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489915
• Sum5<M1Jus>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5489916

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• tremors_Mecp2<tm1.1Bird>/Y,Sum5<M1Jus>/Sum5<+>
  http://metadb.riken.jp/0000745I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum5M1JusSum5Sum5Sum5M1JusMecp2tm11Bird
• tremors_Mecp2<tm1.1Bird>/Y,Sum1<M1Jus>/Sum1<+>
  http://metadb.riken.jp/0000745I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum1M1JusSum1Mecp2tm11BirdSum1M1JusSum1
• malocclusion_Mecp2<tm1.1Bird>/Y,Sum4<M1Jus>/Sum4<+>
  http://metadb.riken.jp/0000120I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum4M1JusSum4Mecp2tm11BirdSum4Sum4M1Jus
• tremors_Mecp2<tm1.1Bird>/Y,Sum2<M1Jus>/Sum2<+>
  http://metadb.riken.jp/0000745I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum2M1JusSum2Mecp2tm11BirdSum2M1JusSum2
• tremors_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0000745I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• malocclusion_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0000120I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• increased circulating LDL cholesterol level_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0000182I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• extended life span_Mecp2<tm1.1Bird>/Y,Sum5<M1Jus>/Sum5<+>
  http://metadb.riken.jp/0001661I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum5M1JusSum5Sum5Sum5M1JusMecp2tm11Bird
• abnormal body weight_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0001259I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• limb grasping_Mecp2<tm1.1Bird>/Y,Sum2<M1Jus>/Sum2<+>
  http://metadb.riken.jp/0001513I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum2M1JusSum2Mecp2tm11BirdSum2M1JusSum2
• lethargy_Mecp2<tm1.1Bird>/Y,Sum1<M1Jus>/Sum1<+>
  http://metadb.riken.jp/0005202I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum1M1JusSum1Mecp2tm11BirdSum1M1JusSum1
• lethargy_Mecp2<tm1.1Bird>/Y,Sum2<M1Jus>/Sum2<+>
  http://metadb.riken.jp/0005202I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum2M1JusSum2Mecp2tm11BirdSum2M1JusSum2
• decreased startle reflex_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0001489I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• abnormal body weight_Mecp2<tm1.1Bird>/Y,Sum5<M1Jus>/Sum5<+>
  http://metadb.riken.jp/0001259I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum5M1JusSum5Sum5Sum5M1JusMecp2tm11Bird
• increased circulating cholesterol level_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0005178I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• embryonic lethality, complete penetrance_Sqle<Sum3-Jus>/Sqle<Sum3-Jus>
  http://metadb.riken.jp/0011092I129P2OlaHsd129S6SvEvTacC57BL6JSqleSum3JusSqleSum3JusSqleSum3Jus
• limb grasping_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0001513I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• extended life span_Mecp2<tm1.1Bird>/Y,Sum1<M1Jus>/Sum1<+>
  http://metadb.riken.jp/0001661I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum1M1JusSum1Mecp2tm11BirdSum1M1JusSum1
• tremors_Mecp2<tm1.1Bird>/Y,Sum4<M1Jus>/Sum4<+>
  http://metadb.riken.jp/0000745I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum4M1JusSum4Mecp2tm11BirdSum4Sum4M1Jus
• premature death_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• dermatitis_Mecp2<tm1.1Bird>/Y,Sum4<M1Jus>/Sum4<+>
  http://metadb.riken.jp/0001194I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum4M1JusSum4Mecp2tm11BirdSum4Sum4M1Jus
• dermatitis_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0001194I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• lethargy_Mecp2<tm1.1Bird>/Y,Sum5<M1Jus>/Sum5<+>
  http://metadb.riken.jp/0005202I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum5M1JusSum5Sum5Sum5M1JusMecp2tm11Bird
• lethargy_Mecp2<tm1.1Bird>/Y,Sum4<M1Jus>/Sum4<+>
  http://metadb.riken.jp/0005202I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum4M1JusSum4Mecp2tm11BirdSum4Sum4M1Jus
• increased pulmonary respiratory rate_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0005573I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• increased brain cholesterol level_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0010162I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• eye inflammation_Mecp2<tm1.1Bird>/Y,Sum4<M1Jus>/Sum4<+>
  http://metadb.riken.jp/0001851I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum4M1JusSum4Mecp2tm11BirdSum4Sum4M1Jus
• decreased body weight_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001262I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• limb grasping_Mecp2<tm1.1Bird>/Y,Sum4<M1Jus>/Sum4<+>
  http://metadb.riken.jp/0001513I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum4M1JusSum4Mecp2tm11BirdSum4Sum4M1Jus
• increased liver triglyceride level_Mecp2<tm1.1Jae>/Y
  http://metadb.riken.jp/0009355B6CgMecp2tm11JaeMecp2tm11JaeYMecp2tm11Jae
• eye inflammation_Mecp2<tm1.1Bird>/Y,Sum2<M1Jus>/Sum2<+>
  http://metadb.riken.jp/0001851I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum2M1JusSum2Mecp2tm11BirdSum2M1JusSum2
• limb grasping_Mecp2<tm1.1Bird>/Y,Sum1<M1Jus>/Sum1<+>
  http://metadb.riken.jp/0001513I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum1M1JusSum1Mecp2tm11BirdSum1M1JusSum1
• eye inflammation_Mecp2<tm1.1Bird>/Y,Sum5<M1Jus>/Sum5<+>
  http://metadb.riken.jp/0001851I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum5M1JusSum5Sum5Sum5M1JusMecp2tm11Bird
• extended life span_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0001661I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• tremors_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0000745I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• increased pulmonary respiratory rate_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0005573I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• decreased startle reflex_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001489I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• impaired coordination_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001405I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• malocclusion_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0000120I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• abnormal body weight_Mecp2<tm1.1Bird>/Y,Sum2<M1Jus>/Sum2<+>
  http://metadb.riken.jp/0001259I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum2M1JusSum2Mecp2tm11BirdSum2M1JusSum2
• increased circulating triglyceride level_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001552I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• extended life span_Mecp2<tm1.1Bird>/Y,Sum4<M1Jus>/Sum4<+>
  http://metadb.riken.jp/0001661I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum4M1JusSum4Mecp2tm11BirdSum4Sum4M1Jus
• increased liver triglyceride level_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0009355I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• limb grasping_Mecp2<tm1.1Bird>/Y,Sum5<M1Jus>/Sum5<+>
  http://metadb.riken.jp/0001513I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum5M1JusSum5Sum5Sum5M1JusMecp2tm11Bird
• extended life span_Mecp2<tm1.1Bird>/Y,Sum2<M1Jus>/Sum2<+>
  http://metadb.riken.jp/0001661I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum2M1JusSum2Mecp2tm11BirdSum2M1JusSum2
• lethargy_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0005202I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• limb grasping_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001513I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• impaired coordination_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0001405I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• increased brain cholesterol level_Mecp2<tm1.1Jae>/Y
  http://metadb.riken.jp/0010162B6CgMecp2tm11JaeMecp2tm11JaeYMecp2tm11Jae
• hypoactivity_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0001402I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird
• abnormal locomotor activation_Mecp2<tm1.1Bird>/Y,Sqle<Sum3-Jus>/Sqle<+>
  http://metadb.riken.jp/0003313I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSqleSum3JusSqleMecp2tm11BirdSqleSum3JusSqle
• dermatitis_Mecp2<tm1.1Bird>/Y,Sum2<M1Jus>/Sum2<+>
  http://metadb.riken.jp/0001194I129P2OlaHsd129S6SvEvTacC57BL6JMecp2tm11BirdYSum2M1JusSum2Mecp2tm11BirdSum2M1JusSum2
• lethargy_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0005202I129P2OlaHsd129S6SvEvTacMecp2tm11BirdYMecp2tm11Bird