Irini. Manoli, et.al., Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/23898205

Irini. Manoli, et.al., Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Alb-Mut)#Cpv
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527452

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal blood homeostasis_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0009642IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• decreased renal glomerular filtration rate_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0005528IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• abnormal mitochondrial matrix morphology_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0011637IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• abnormal kidney morphology_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0002135IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• decreased circulating bicarbonate level_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0003017IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• weight loss_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0001263IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• premature death_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0002083IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• metabolic acidosis_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0012551IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• abnormal mitochondrial crista morphology_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0011635IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• oxidative stress_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0003674IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• abnormal renal tubule morphology_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0002703IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• abnormal brain morphology_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0002152IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• abnormal renal reabsorbtion_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0010107IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• increased circulating creatinine level_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0005553IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• increased circulating chloride level_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0003019IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv
• tubulointerstitial nephritis_Mut<tm1Cpv>/Mut<tm1Cpv>,Tg(Alb-Mut)#Cpv/0
  http://metadb.riken.jp/0011405IC57BL6Muttm1CpvMuttm1CpvTgAlbMutCpv0Muttm1CpvTgAlbMutCpv

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Alb-Mut)#Cpv
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527452