Marie. Le Bouteiller, et.al., Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells., The Journal of experimental medicine, 2013, 210

http://rdf.ncbi.nlm.nih.gov/pubmed/24062412

Marie. Le Bouteiller, et.al., Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells., The Journal of experimental medicine, 2013, 210

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nle1<tm1.2Cota>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5553358
• Nle1<tm1.1Cota>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5553357

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired hematopoiesis_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001606I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• abnormal common lymphocyte progenitor cell morphology_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008249I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• abnormal immune system organ morphology_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002722I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• abnormal embryo development_Nle1<tm1.2Cota>/Nle1<tm1.2Cota>
  http://metadb.riken.jp/0001672I129S2SvPasNle1tm12CotaNle1tm12CotaNle1tm12Cota
• failure of blastocyst to hatch from the zona pellucida_Nle1<tm1.2Cota>/Nle1<tm1.2Cota>
  http://metadb.riken.jp/0003694I129S2SvPasNle1tm12CotaNle1tm12CotaNle1tm12Cota
• decreased NK cell number_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008045I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• abnormal cell morphology_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000358I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• premature death_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• decreased common myeloid progenitor cell number_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008813I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• abnormal hematopoietic stem cell physiology_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010763I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• abnormal intestinal epithelium morphology_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000488I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• decreased macrophage cell number_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003884I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• decreased granulocyte number_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000334I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• spleen hypoplasia_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000694I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• abnormal bone marrow cell morphology/development_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002398I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• decreased T cell number_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005018I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• thymus hypoplasia_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001823I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota
• decreased bone marrow cell number_Nle1<tm1Cba>/Nle1<tm1.1Cota>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000333I129P2OlaHsd129S2SvPasNle1tm1CbaNle1tm11CotaGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnNle1tm1CbaGtROSA26SorNle1tm11Cota

class

http://purl.org/net/cito/citesAsAuthority

• Nle1<tm1.2Cota>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5553358
• Nle1<tm1.1Cota>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5553357