Samantha B. Foley, et.al., Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia., Cell reports, 2013, 5

http://rdf.ncbi.nlm.nih.gov/pubmed/24095735

Samantha B. Foley, et.al., Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia., Cell reports, 2013, 5

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Vav1-cre)#Cgp
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527187
• Bcr<tm1(BCR/ABL)Tsr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5524984

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Vav1-cre)#Cgp
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527187
• Bcr<tm1(BCR/ABL)Tsr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5524984

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• no abnormal phenotype detected_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0002169IBALBcC57BL6Bcrtm1BCRABLTsrBcrTgCMVcre1Cgn0Bcrtm1BCRABLTsrBcrTgCMVcre1Cgn
• decreased hematopoietic stem cell number_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>
  http://metadb.riken.jp/0004810C57BL6Bcrtm1BCRABLTsrBcrtm1BCRABLTsrBcrBcrtm1BCRABLTsrBcr
• decreased lymphocyte cell number_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Vav1-cre)#Cgp/0
  http://metadb.riken.jp/0005016IC57BL6Bcrtm1BCRABLTsrBcrRunx1tm3DowRunx1TgVav1creCgp0Bcrtm1BCRABLTsrTgVav1creCgpBcrRunx1tm3DowRunx1
• no abnormal phenotype detected_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002169IC57BL6CBABcrtm1BCRABLTsrBcrTgMx1cre1Cgn0TgMx1cre1CgnBcrtm1BCRABLTsrBcr
• premature death_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Vav1-cre)#Cgp/0
  http://metadb.riken.jp/0002083IC57BL6Bcrtm1BCRABLTsrBcrRunx1tm3DowRunx1TgVav1creCgp0Bcrtm1BCRABLTsrTgVav1creCgpBcrRunx1tm3DowRunx1
• thrombocytopenia_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Vav1-cre)#Cgp/0
  http://metadb.riken.jp/0003179IC57BL6Bcrtm1BCRABLTsrBcrRunx1tm3DowRunx1TgVav1creCgp0Bcrtm1BCRABLTsrTgVav1creCgpBcrRunx1tm3DowRunx1
• abnormal bone marrow cell physiology_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>
  http://metadb.riken.jp/0009278C57BL6Bcrtm1BCRABLTsrBcrtm1BCRABLTsrBcrBcrtm1BCRABLTsrBcr
• abnormal bone marrow cell physiology_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Tg(Vav1-cre)#Cgp/0
  http://metadb.riken.jp/0009278IC57BL6Bcrtm1BCRABLTsrBcrTgVav1creCgp0Bcrtm1BCRABLTsrTgVav1creCgpBcr
• increased monocyte cell number_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Vav1-cre)#Cgp/0
  http://metadb.riken.jp/0000220IC57BL6Bcrtm1BCRABLTsrBcrRunx1tm3DowRunx1TgVav1creCgp0Bcrtm1BCRABLTsrTgVav1creCgpBcrRunx1tm3DowRunx1
• increased neutrophil cell number_Bcr<tm1(BCR/ABL)Tsr>/Bcr<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Vav1-cre)#Cgp/0
  http://metadb.riken.jp/0000219IC57BL6Bcrtm1BCRABLTsrBcrRunx1tm3DowRunx1TgVav1creCgp0Bcrtm1BCRABLTsrTgVav1creCgpBcrRunx1tm3DowRunx1
• no abnormal phenotype detected_Bcr<tm1(BCR/ABL)Tsr>/Bcr<tm1(BCR/ABL)Tsr>,Tg(Vav1-cre)#Cgp/0
  http://metadb.riken.jp/0002169IC57BL6Bcrtm1BCRABLTsrBcrtm1BCRABLTsrTgVav1creCgp0TgVav1creCgpBcrtm1BCRABLTsr