Sergei. Gaidamakov, et.al., Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss., Molecular and cellular biology, 2014, 34

http://rdf.ncbi.nlm.nih.gov/pubmed/24190965

Sergei. Gaidamakov, et.al., Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss., Molecular and cellular biology, 2014, 34

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ssb<tm2.1Rjma>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569491
• Ssb<tm2Rjma>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569489

class

http://purl.org/net/cito/citesAsAuthority

• Ssb<tm2.1Rjma>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569491
• Ssb<tm2Rjma>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569489

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal neuron morphology_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0002882I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl
• decreased IgG level_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0001805I129SSvEvBALBcSsbtm1RjmaSsbtm21RjmaCd79atm1creRethCd79aSsbtm1RjmaCd79atm1creRethCd79aSsbtm21Rjma
• abnormal cerebral cortex morphology_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0000788I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl
• decreased brain weight_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0002175I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl
• neurodegeneration_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0002229I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl
• decreased forebrain size_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0012138I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl
• decreased spleen weight_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0004953I129SSvEvBALBcSsbtm1RjmaSsbtm21RjmaCd79atm1creRethCd79aSsbtm1RjmaCd79atm1creRethCd79aSsbtm21Rjma
• thin cerebral cortex_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0006254I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl
• embryonic lethality, complete penetrance_Ssb<tm2Rjma>/Ssb<tm2Rjma>
  http://metadb.riken.jp/0011092NSSsbtm2RjmaSsbtm2RjmaSsbtm2Rjma
• forebrain hypoplasia_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0000784I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl
• small spleen_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0000692I129SSvEvBALBcSsbtm1RjmaSsbtm21RjmaCd79atm1creRethCd79aSsbtm1RjmaCd79atm1creRethCd79aSsbtm21Rjma
• decreased IgM level_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0001806I129SSvEvBALBcSsbtm1RjmaSsbtm21RjmaCd79atm1creRethCd79aSsbtm1RjmaCd79atm1creRethCd79aSsbtm21Rjma
• decreased B cell number_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0005017I129SSvEvBALBcSsbtm1RjmaSsbtm21RjmaCd79atm1creRethCd79aSsbtm1RjmaCd79atm1creRethCd79aSsbtm21Rjma
• arrested B cell differentiation_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0001802I129SSvEvBALBcSsbtm1RjmaSsbtm21RjmaCd79atm1creRethCd79aSsbtm1RjmaCd79atm1creRethCd79aSsbtm21Rjma
• hippocampus pyramidal cell degeneration_Ssb<tm1Rjma>/Ssb<tm2.1Rjma>,Tg(Camk2a-cre)T29-1Stl/0
  http://metadb.riken.jp/0010014I129SSvEvBALBcC57BLC57BL6Ssbtm1RjmaSsbtm21RjmaTgCamk2acreT291Stl0Ssbtm21RjmaSsbtm1RjmaTgCamk2acreT291Stl