Nadine. Hövelmeyer, et.al., Overexpression of Bcl-3 inhibits the development of marginal zone B cells., European journal of immunology, 2014, 44

http://rdf.ncbi.nlm.nih.gov/pubmed/24242374

Nadine. Hövelmeyer, et.al., Overexpression of Bcl-3 inhibits the development of marginal zone B cells., European journal of immunology, 2014, 44

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5574111

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5574111

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal Peyer's patch germinal center morphology_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002391I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• enlarged spleen_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased immature B cell number_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008215I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased B-1a cell number_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008168I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• abnormal transitional stage T3 B cell morphology_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0009921I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased transitional stage T1 B cell number_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0009923I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased B cell apoptosis_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008783I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• increased lymphocyte cell number_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005013I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• abnormal follicular B cell morphology_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008172I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased marginal zone B cell number_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008182I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• abnormal class switch recombination_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004816I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased IgG3 level_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008498I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased IgG2b level_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008497I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased B cell proliferation_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005093I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased IgG1 level_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008495I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• abnormal B-2 B cell morphology_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008166I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased IgM level_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0001806I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• absent marginal zone B cells_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008183I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• decreased B-1 B cell number_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004978I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev
• abnormal B cell differentiation_Gt(ROSA)26Sor<tm1(CAG-Bcl3,-EGFP)Hoev>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002144I129P2OlaHsdGtROSA26Sortm1CAGBcl3EGFPHoevGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnCd19GtROSA26SorGtROSA26Sortm1CAGBcl3EGFPHoev