Emily. Bailey, et.al., FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/24255108

Emily. Bailey, et.al., FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Flt3<tm2.1Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565506
• Flt3<tm1.1Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565508
• Flt3<tm2Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565509

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal bone marrow cell number_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000172B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• increased leukocyte cell number_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000218B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• extramedullary hematopoiesis_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000240B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• increased bone marrow cell number_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000321B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• increased bone marrow cell number_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000321B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• decreased bone marrow cell number_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000333B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
他26件を見る
• abnormal spleen morphology_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000689B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• abnormal spleen morphology_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000689B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• enlarged spleen_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000691B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• enlarged spleen_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0000691B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• abnormal myelopoiesis_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0001601B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• arrested B cell differentiation_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0001802B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• increased B cell derived lymphoma incidence_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0002023B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• premature death_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0002083B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• premature death_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0002083B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• abnormal definitive hematopoiesis_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0002123B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• abnormal definitive hematopoiesis_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0002123B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• abnormal bone marrow morphology_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0002397B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• abnormal bone marrow morphology_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0002397B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• increased hemangiosarcoma incidence_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0003667B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• abnormal B cell morphology_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0004939B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• thrombocytosis_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0005505B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• increased pro-B cell number_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0008186B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• increased megakaryocyte cell number_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0008254B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• intermingled spleen red and white pulp_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0008475B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• increased spleen white pulp amount_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0008478B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• increased spleen white pulp amount_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0008478B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• abnormal bone marrow cell physiology_Flt3<tm1.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0009278B6129CFlt3tm11DosmFlt3tm11DosmFlt3Flt3Flt3tm11Dosm
• abnormal bone marrow cell physiology_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0009278B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• increased histiocytic sarcoma incidence_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0009321B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• myeloid hyperplasia_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0010373B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3
• increased pre-pro B cell number_Flt3<tm2.1Dosm>/Flt3<+>
  http://metadb.riken.jp/0011815B6129CFlt3tm21DosmFlt3tm21DosmFlt3Flt3tm21DosmFlt3

class

http://purl.org/net/cito/citesAsAuthority

• Flt3<tm2.1Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565506
• Flt3<tm1.1Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565508
• Flt3<tm2Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565509