Lee J. Martin, et.al., Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice., Neurobiology of aging, 2014, 35

http://rdf.ncbi.nlm.nih.gov/pubmed/24325796

Lee J. Martin, et.al., Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice., Neurobiology of aging, 2014, 35

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal brain interneuron morphology_Tg(THY1-SNCA*A53T)M53Sud/0
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  http://metadb.riken.jp/0005424B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
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  http://metadb.riken.jp/0001393B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal cerebellum morphology_Tg(THY1-SNCA*A53T)M53Sud/0
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• alpha-synuclein inclusion body_Tg(Slc6a5-EGFP)1Uze/0,Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0008493IC57BL6FVBNTgSlc6a5EGFP1Uze0TgTHY1SNCAA53TM53Sud0TgSlc6a5EGFP1UzeTgTHY1SNCAA53TM53Sud
• abnormal thalamus morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0000832B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• increased neuron apoptosis_Tg(THY1-SNCA*A53T)M53Sud/0
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• abnormal cerebellar layer morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0009956B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal thalamus neuron morphology_Tg(THY1-SNCA*A53T)M53Sud/0
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• abnormal cerebellum white matter morphology_Tg(THY1-SNCA*A53T)M53Sud/0
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• abnormal substantia nigra pars compacta morphology_Tg(THY1-SNCA*A53T)M53Sud/0
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• abnormal nervous system morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0003632B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• neuron degeneration_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0003224B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal cerebellum interpositus nucleus morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0009984B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• bradykinesia_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0005156B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal cerebral cortex pyramidal cell morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0009969B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal superior cerebellar peduncle morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0009987B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal midbrain morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0000897B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• neuronal cytoplasmic inclusions_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0011975B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal cerebellar Golgi cell morphology_Tg(Slc6a5-EGFP)1Uze/0,Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0009512IC57BL6FVBNTgSlc6a5EGFP1Uze0TgTHY1SNCAA53TM53Sud0TgSlc6a5EGFP1UzeTgTHY1SNCAA53TM53Sud
• abnormal hippocampus layer morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0000813B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• premature death_Ppif<tm1Maf>/Ppif<tm1Maf>,Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0002083I129C57BL6Ppiftm1MafPpiftm1MafTgTHY1SNCAA53TM53Sud0Ppiftm1MafTgTHY1SNCAA53TM53Sud
• tremors_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0000745B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal cerebral cortex morphology_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0000788B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• abnormal posture_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0001504B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• axon degeneration_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0005405B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• neurodegeneration_Ppif<tm1Maf>/Ppif<tm1Maf>,Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0002229I129C57BL6Ppiftm1MafPpiftm1MafTgTHY1SNCAA53TM53Sud0Ppiftm1MafTgTHY1SNCAA53TM53Sud
• abnormal gait_Tg(THY1-SNCA*A53T)M53Sud/0
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• abnormal red nucleus morphology_Tg(THY1-SNCA*A53T)M53Sud/0
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• spasticity_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0012051B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud
• premature death_Tg(THY1-SNCA*A53T)M53Sud/0
  http://metadb.riken.jp/0002083B6CgTgTHY1SNCAA53TM53SudJTgTHY1SNCAA53TM53Sud0TgTHY1SNCAA53TM53Sud