Tsutomu. Sasaki, et.al., Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice., Diabetologia, 2014, 57

http://rdf.ncbi.nlm.nih.gov/pubmed/24374551

Tsutomu. Sasaki, et.al., Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice., Diabetologia, 2014, 57

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Sirt1)Ktm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5586719
• Gt(ROSA)26Sor<tm1(Sirt1)Ktm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5586718

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal adaptive thermogenesis_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0011019I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• abnormal noradrenaline level_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0003964I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• decreased susceptibility to age related obesity_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Agrp-cre)1Gsb/0
  http://metadb.riken.jp/0003213I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgAgrpcre1Gsb0GtROSA26SorGtROSA26Sortm1Sirt1KtmTgAgrpcre1Gsb
• decreased circulating thyroxine level_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005478I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• abnormal homeostasis_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Agrp-cre)1Gsb/0
  http://metadb.riken.jp/0001764I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgAgrpcre1Gsb0GtROSA26SorGtROSA26Sortm1Sirt1KtmTgAgrpcre1Gsb
• decreased total body fat amount_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0010025I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• abnormal homeostasis_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001764I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• decreased food intake_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Agrp-cre)1Gsb/0
  http://metadb.riken.jp/0011940I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgAgrpcre1Gsb0GtROSA26SorGtROSA26Sortm1Sirt1KtmTgAgrpcre1Gsb
• increased body weight_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Agrp-cre)1Gsb/0
  http://metadb.riken.jp/0001260I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgAgrpcre1Gsb0GtROSA26SorGtROSA26Sortm1Sirt1KtmTgAgrpcre1Gsb
• increased food intake_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Agrp-cre)1Gsb/0
  http://metadb.riken.jp/0011939I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgAgrpcre1Gsb0GtROSA26SorGtROSA26Sortm1Sirt1KtmTgAgrpcre1Gsb
• increased energy expenditure_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0004889I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• increased oxygen consumption_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005289I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• decreased susceptibility to age related obesity_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0003213I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• decreased epididymal fat pad weight_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0009289I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl
• hypoactivity_Gt(ROSA)26Sor<tm1(Sirt1)Ktm>/Gt(ROSA)26Sor<+>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001402I129C57BL6JFVBNGtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl0GtROSA26Sortm1Sirt1KtmGtROSA26SorTgPomc1cre16Lowl

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Sirt1)Ktm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5586719
• Gt(ROSA)26Sor<tm1(Sirt1)Ktm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5586718