David. Frescas, et.al., A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice., Genes & development, 2014, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/24449270

David. Frescas, et.al., A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice., Genes & development, 2014, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tinf2<tm2.1Tdl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556226
• Tinf2<tm2.2Tdl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556393

class

http://purl.org/net/cito/citesAsAuthority

• Tinf2<tm2.1Tdl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556226
• Tinf2<tm2.2Tdl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556393

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• gliosis_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0002183IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• decreased body weight_Tinf2<tm2.1Tdl>/Tinf2<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0001262IBALBcJC57BL6Tinf2tm21TdlTinf2TgCMVcre1Cgn0TgCMVcre1CgnTinf2tm21TdlTinf2
• pancytopenia_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0005152IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• embryonic lethality, complete penetrance_Tinf2<tm2.2Tdl>/Tinf2<tm2.2Tdl>
  http://metadb.riken.jp/0011092IBALBcJC57BL6Tinf2tm22TdlTinf2tm22TdlTinf2tm22Tdl
• testicular atrophy_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0003205IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• abnormal telomere length_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0003155IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• myeloid hyperplasia_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0010373IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• lymphoid hyperplasia_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0000688IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• abnormal telomere length_Terc<tm1Rdp>/Terc<tm1Rdp>,Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0003155I129BALBcJC57BL6SJLTerctm1RdpTerctm1RdpTinf2tm22TdlTinf2Terctm1RdpTinf2tm22TdlTinf2
• decreased birth body size_Tinf2<tm2.1Tdl>/Tinf2<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0009703IBALBcJC57BL6Tinf2tm21TdlTinf2TgCMVcre1Cgn0TgCMVcre1CgnTinf2tm21TdlTinf2
• no abnormal phenotype detected_Tinf2<tm2.1Tdl>/Tinf2<tm2.1Tdl>
  http://metadb.riken.jp/0002169IC57BL6Tinf2tm21TdlTinf2tm21TdlTinf2tm21Tdl
• seizures_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0002064IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• dermatitis_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0001194IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• reduced fertility_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0001921IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• seminiferous tubule degeneration_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0001154IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• hydroencephaly_Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0001891IBALBcJC57BL6Tinf2tm22TdlTinf2Tinf2Tinf2tm22Tdl
• abnormal chromosome morphology_Terc<tm1Rdp>/Terc<tm1Rdp>,Tinf2<tm2.2Tdl>/Tinf2<+>
  http://metadb.riken.jp/0003702I129BALBcJC57BL6SJLTerctm1RdpTerctm1RdpTinf2tm22TdlTinf2Terctm1RdpTinf2tm22TdlTinf2
• prenatal lethality, incomplete penetrance_Tinf2<tm2.1Tdl>/Tinf2<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0011101IBALBcJC57BL6Tinf2tm21TdlTinf2TgCMVcre1Cgn0TgCMVcre1CgnTinf2tm21TdlTinf2