Huw B. Jones, et.al., Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis., International journal of experimental pathology, 2014, 95

http://rdf.ncbi.nlm.nih.gov/pubmed/24456331

Huw B. Jones, et.al., Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis., International journal of experimental pathology, 2014, 95

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased circulating glucagon level_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0002696B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• increased circulating insulin level_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0002079B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• premature death_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0002083B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• improved glucose tolerance_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0005292B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• increased pancreatic ductal adenocarcinoma incidence_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0009151B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• abnormal pancreatic alpha cell differentiation_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0009179B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• enlarged pancreatic islets_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0009171B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• increased pancreatic alpha cell number_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0009176B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• increased pancreas tumor incidence_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0009153B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• increased pancreatic islet cell adenoma incidence_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0003430B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• pancreatic islet hyperplasia_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0005491B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• decreased glucagon secretion_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0002711B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• abnormal pancreatic alpha cell morphology_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0005216B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs
• dilated renal tubules_Pcsk2<tm1Dfs>/Pcsk2<tm1Dfs>
  http://metadb.riken.jp/0002705B6129Pcsk2tm1DfsJPcsk2tm1DfsPcsk2tm1DfsPcsk2tm1Dfs