Ramon. Roset, et.al., The Rad50 hook domain regulates DNA damage signaling and tumorigenesis., Genes & development, 2014, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/24532689

Ramon. Roset, et.al., The Rad50 hook domain regulates DNA damage signaling and tumorigenesis., Genes & development, 2014, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Rad50<tm4.1Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5614069
• Rad50<tm4Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5614068
• Rad50<tm5Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5614071

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• testicular atrophy_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0003205I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• ovary atrophy_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0004833I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• prenatal lethality, complete penetrance_Rad50<tm1Jpt>/Rad50<tm4.1Jpt>
  http://metadb.riken.jp/0011091I129Sv129S7SvEvBrdC57BL6Rad50tm1JptRad50tm41JptRad50tm1JptRad50tm41Jpt
• male infertility_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001925I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• increased liver adenoma incidence_Rad50<tm4Jpt>/Rad50<+>
  http://metadb.riken.jp/0003324I129SvC57BL6Rad50tm4JptRad50Rad50Rad50tm4Jpt
• hydroencephaly_Rad50<tm4Jpt>/Rad50<+>
  http://metadb.riken.jp/0001891I129SvC57BL6Rad50tm4JptRad50Rad50Rad50tm4Jpt
• increased hepatoblastoma incidence_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0010054I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal sperm number_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0002673I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal testis size_Atm<tm1Awb>/Atm<+>,Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0004849I129Sv129S6SvEvTacC57BL6Atmtm1AwbAtmRad50tm41JptRad50Rad50tm41JptAtmRad50Atmtm1Awb
• increased liver adenoma incidence_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0003324I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• increased liver tumor incidence_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0008019I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• female infertility_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001926I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• prenatal lethality, complete penetrance_Rad50<tm5Jpt>/Rad50<+>
  http://metadb.riken.jp/0011091I129SvC57BL6Rad50tm5JptRad50Rad50tm5JptRad50
• abnormal hematopoietic stem cell morphology_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0004808I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal fertility/fecundity_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0002161I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal intestine morphology_Rad50<tm1Jpt>/Rad50<tm3Jpt>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000477I129SvC57BL6Rad50tm1JptRad50tm3JptGtROSA26Sortm1creERT2TyjGtROSA26SorGtROSA26Sortm1creERT2TyjGtROSA26SorRad50tm3JptRad50tm1Jpt
• abnormal gametogenesis_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001929I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• postnatal lethality, complete penetrance_Rad50<tm1Jpt>/Rad50<tm3Jpt>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011085I129SvC57BL6Rad50tm1JptRad50tm3JptGtROSA26Sortm1creERT2TyjGtROSA26SorGtROSA26Sortm1creERT2TyjGtROSA26SorRad50tm3JptRad50tm1Jpt
• abnormal seminiferous tubule morphology_Atm<tm1Awb>/Atm<+>,Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0002216I129Sv129S6SvEvTacC57BL6Atmtm1AwbAtmRad50tm41JptRad50Rad50tm41JptAtmRad50Atmtm1Awb
• hydroencephaly_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001891I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• reduced female fertility_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001923I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• postnatal lethality, complete penetrance_Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<+>,Rad50<tm3Jpt>/Rad50<tm4.1Jpt>
  http://metadb.riken.jp/0011085I129SvC57BL6GtROSA26Sortm1creERT2TyjGtROSA26SorRad50tm3JptRad50tm41JptGtROSA26Sortm1creERT2TyjGtROSA26SorRad50tm41JptRad50tm3Jpt
• hyperpigmentation_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001188I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal intestine morphology_Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<+>,Rad50<tm3Jpt>/Rad50<tm4.1Jpt>
  http://metadb.riken.jp/0000477I129SvC57BL6GtROSA26Sortm1creERT2TyjGtROSA26SorRad50tm3JptRad50tm41JptGtROSA26Sortm1creERT2TyjGtROSA26SorRad50tm41JptRad50tm3Jpt
• increased tail pigmentation_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0011276I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal seminiferous tubule morphology_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0002216I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal seminiferous tubule morphology_Rad50<tm4.1Jpt>/Rad50<+>,Spo11<tm1Mjn>/Spo11<tm1Mjn>
  http://metadb.riken.jp/0002216I129SvC57BL6Rad50tm41JptRad50Spo11tm1MjnSpo11tm1MjnRad50Spo11tm1MjnRad50tm41Jpt
• increased liver tumor incidence_Rad50<tm4Jpt>/Rad50<+>
  http://metadb.riken.jp/0008019I129SvC57BL6Rad50tm4JptRad50Rad50Rad50tm4Jpt
• small testis_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001147I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• decreased litter size_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001935I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• impaired hematopoiesis_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001606I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• increased foot pad pigmentation_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0000575I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• abnormal spermatogenesis_Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0001156I129SvC57BL6Rad50tm41JptRad50Rad50tm41JptRad50
• increased tumor latency_Atm<tm1Awb>/Atm<tm1Awb>,Rad50<tm4.1Jpt>/Rad50<+>
  http://metadb.riken.jp/0009828I129Sv129S6SvEvTacC57BL6Atmtm1AwbAtmtm1AwbRad50tm41JptRad50Atmtm1AwbRad50Rad50tm41Jpt

class

http://purl.org/net/cito/citesAsAuthority

• Rad50<tm4.1Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5614069
• Rad50<tm4Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5614068
• Rad50<tm5Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5614071