L. Chung, et.al., The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers., Oncogene, 2015, 34

http://rdf.ncbi.nlm.nih.gov/pubmed/24608430

L. Chung, et.al., The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers., Oncogene, 2015, 34

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5629667

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal double-strand DNA break repair_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0010948I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• decreased fibroblast proliferation_Fen1<tm2.1Bhsh>/Fen1<+>
  http://metadb.riken.jp/0011704I129S1SvFen1tm21BhshFen1Fen1Fen1tm21Bhsh
• abnormal cell physiology_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0005621I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• aneuploidy_Fen1<tm2.1Bhsh>/Fen1<+>
  http://metadb.riken.jp/0004024I129S1SvFen1tm21BhshFen1Fen1Fen1tm21Bhsh
• increased thymus tumor incidence_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0010365I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• spontaneous chromosome breakage_Fen1<tm2.1Bhsh>/Fen1<+>
  http://metadb.riken.jp/0004029I129S1SvFen1tm21BhshFen1Fen1Fen1tm21Bhsh
• abnormal telomere morphology_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0010207I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• chromosomal instability_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0008866I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• decreased fibroblast proliferation_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0011704I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• increased liver tumor incidence_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0008019I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• increased tumor incidence_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0002020I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• spontaneous chromosome breakage_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0004029I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• aneuploidy_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0004024I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh
• increased lung tumor incidence_Fen1<tm2.1Bhsh>/Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/0008014I129S1SvFen1tm21BhshFen1tm21BhshFen1tm21Bhsh

class

http://purl.org/net/cito/citesAsAuthority

• Fen1<tm2.1Bhsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5629667