Bernd. Kinzel, et.al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice., Developmental biology, 2014, 390

http://rdf.ncbi.nlm.nih.gov/pubmed/24680895

Bernd. Kinzel, et.al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice., Developmental biology, 2014, 390

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635820
• Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635821

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased hair follicle number_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0000379IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• perinatal lethality, complete penetrance_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011089IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal glomerular capsule space morphology_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011499IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal intestine development_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0010158IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• thin epidermis_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0001218IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• perinatal lethality, complete penetrance_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011089IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal epidermal stem cell proliferation_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011006IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• decreased hair follicle number_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0000379IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal skin development_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0003941IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• perinatal lethality, complete penetrance_Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011089IC57BL6Lgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2Npa
• abnormal skin development_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0003941IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal intestine physiology_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0010155IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• thin epidermis_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0001218IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• decreased kidney cell proliferation_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011441IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• prenatal lethality, incomplete penetrance_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011101IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal epidermal stem cell proliferation_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011006IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• prenatal lethality, incomplete penetrance_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0011101IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• kidney cysts_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0003675IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal intestine physiology_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0010155IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal hair follicle development_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0003704IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• abnormal intestine development_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>,Lgr5<tm1.1(cre/ERT2)Npa>/Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0010158IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr5tm11creERT2NpaLgr4tm11creERT2Npa
• dilated renal tubules_Lgr4<tm1.1(cre/ERT2)Npa>/Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/0002705IC57BL6Lgr4tm11creERT2NpaLgr4tm11creERT2NpaLgr4tm11creERT2Npa

class

http://purl.org/net/cito/citesAsAuthority

• Lgr4<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635820
• Lgr5<tm1.1(cre/ERT2)Npa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635821