Lalit. Kumar, et.al., Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function., The Journal of experimental medicine, 2014, 211

http://rdf.ncbi.nlm.nih.gov/pubmed/24752297

Lalit. Kumar, et.al., Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function., The Journal of experimental medicine, 2014, 211

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5581436

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperkeratosis_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0001242B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased thymocyte number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0000715B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased T cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0005018B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased pre-B cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008209B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal T cell differentiation_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0002145B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal renal tubule morphology_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0002703B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased marginal zone B cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008182B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal B cell differentiation_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0002144B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased double-positive T cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0005092B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• increased thymocyte apoptosis_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0009541B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• premature death_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0002083B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• absent thymus corticomedullary boundary_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0013741B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased transitional stage B cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008190B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased DN2 thymocyte number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0010132B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• paraparesis_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0009434B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal T cell selection_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0004917B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased T cell proliferation_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0005095B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal thymus apoptosis_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0014180B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• increased regulatory T cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0004973B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased CD4-positive, alpha beta T cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008075B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased double-negative T cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0005089B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• prenatal lethality, incomplete penetrance_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0011101B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• small thymus cortex_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0013592B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• thymus hypoplasia_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0001823B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• increased IgG2a level_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008500B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• hydronephrosis_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0000519B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased DN4 thymocyte number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0010136B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• infertility_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0001924B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased B cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0005017B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal thymus physiology_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0003763B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• waved hair_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0000410B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal thymus medulla morphology_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0002375B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased DN3 thymocyte number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0010134B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal T cell physiology_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0002444B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• small spleen_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0000692B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased immature B cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008215B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased body weight_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0001262B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal thymus morphology_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0000703B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• postnatal growth retardation_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0001732B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• absent corpus luteum_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0001134B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• increased pro-B cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008186B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• abnormal skeletal muscle morphology_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0000759B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• small thymus_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0000706B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha
• decreased CD8-positive, alpha-beta T cell number_Lrrc8a<tm1.1Geha>/Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/0008079B6129S1CgLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11GehaLrrc8atm11Geha

class

http://purl.org/net/cito/citesAsAuthority

• Lrrc8a<tm1.1Geha>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5581436