John T. Cunningham, et.al., Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer., Cell, 2014, 157

http://rdf.ncbi.nlm.nih.gov/pubmed/24855946

John T. Cunningham, et.al., Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer., Cell, 2014, 157

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal B cell physiology_Prps2<tm1a(KOMP)Wtsi>/Y,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0002459IC57BL6NSJLPrps2tm1aKOMPWtsiYTgIghMyc22Bri0Prps2tm1aKOMPWtsiTgIghMyc22Bri
• abnormal B cell physiology_Prps2<tm1a(KOMP)Wtsi>/Y
  http://metadb.riken.jp/0002459IC57BL6NPrps2tm1aKOMPWtsiYPrps2tm1aKOMPWtsi
• premature death_Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0002083IC57BL6NSJLTgIghMyc22Bri0TgIghMyc22Bri
• increased B cell apoptosis_Prps2<tm1a(KOMP)Wtsi>/Y,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0008782IC57BL6NSJLPrps2tm1aKOMPWtsiYTgIghMyc22Bri0Prps2tm1aKOMPWtsiTgIghMyc22Bri
• increased tumor latency_Prps2<tm1a(KOMP)Wtsi>/Y,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0009828IC57BL6NSJLPrps2tm1aKOMPWtsiYTgIghMyc22Bri0Prps2tm1aKOMPWtsiTgIghMyc22Bri
• increased B cell apoptosis_Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0008782IC57BL6NSJLTgIghMyc22Bri0TgIghMyc22Bri
• increased lymphoma incidence_Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0012431IC57BL6NSJLTgIghMyc22Bri0TgIghMyc22Bri
• abnormal survival_Prps2<tm1a(KOMP)Wtsi>/Y,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0010769IC57BL6NSJLPrps2tm1aKOMPWtsiYTgIghMyc22Bri0Prps2tm1aKOMPWtsiTgIghMyc22Bri