Randy T. Cowling, et.al., Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse., American journal of physiology. Heart and circulatory physiology, 2014, 307

http://rdf.ncbi.nlm.nih.gov/pubmed/24993042

Randy T. Cowling, et.al., Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse., American journal of physiology. Heart and circulatory physiology, 2014, 307

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ddr2<tm2.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662371
• Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662369

class

http://purl.org/net/cito/citesAsAuthority

• Ddr2<tm2.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662371
• Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662369

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cranium morphology_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0000438I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• abnormal cardiac muscle relaxation_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0004084I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• short tibia_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0002764I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• decreased collagen level_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0020254I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• short limbs_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0000547I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• small heart_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0002188I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• abnormal heart morphology_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0000266I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• reduced fertility_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0001921I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• decreased body weight_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• abnormal heart echocardiography feature_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0011925I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• infertility_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0001924I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• abnormal snout morphology_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0000443I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• small myocardial fiber_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0004565I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• pregnancy-related premature death_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0008028I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• abnormal heart left ventricle pressure_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0010754I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• decreased heart weight_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0002834I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow
• decreased cardiac muscle contractility_Ddr2<tm1.1(cre/Esr1*)Rcow>/Ddr2<tm1.1(cre/Esr1*)Rcow>
  http://metadb.riken.jp/0005140I129S1Sv129X1SvJC57BL6Ddr2tm11creEsr1RcowDdr2tm11creEsr1RcowDdr2tm11creEsr1Rcow