Alexander. Jais, et.al., Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man., Cell, 2014, 158

http://rdf.ncbi.nlm.nih.gov/pubmed/24995976

Alexander. Jais, et.al., Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man., Cell, 2014, 158

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hmox1<tm1.1Hes>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5649369

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased inflammatory response_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0001876I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• abnormal redox activity_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003186IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• decreased circulating alanine transaminase level_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002942IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• decreased circulating free fatty acid level_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002702I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• abnormal metabolism_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005266IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• improved glucose tolerance_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0005292I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• increased energy expenditure_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0004889I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• abnormal cellular respiration_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0010954I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• decreased interleukin-1 beta secretion_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008658I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• abnormal metabolism_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0005266I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• increased insulin sensitivity_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002891I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• decreased tumor necrosis factor secretion_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008561I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• decreased susceptibility to hepatic steatosis_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002310I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• increased insulin sensitivity_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002891IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• decreased interleukin-6 secretion_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008706I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• decreased susceptibility to hepatic steatosis_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002310IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• abnormal mitochondrial physiology_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0006036I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• abnormal cellular respiration_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010954IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• abnormal mitochondrial physiology_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0006036IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• abnormal redox activity_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0003186I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• decreased circulating aspartate transaminase level_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005632IC57BL6C57BL6JC57BL6NDBAHmox1tm11HesHmox1tm11HesTgAlbcre21Mgn0TgAlbcre21MgnHmox1tm11Hes
• decreased fat cell size_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0009269I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes
• decreased susceptibility to weight gain_Hmox1<tm1.1Hes>/Hmox1<tm1.1Hes>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0010182I129P2OlaHsdC57BL6JC57BL6NHmox1tm11HesHmox1tm11HesLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Hes

class

http://purl.org/net/cito/citesAsAuthority

• Hmox1<tm1.1Hes>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5649369