Kaja. Plucińska, et.al., Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, 34

http://rdf.ncbi.nlm.nih.gov/pubmed/25100603

Kaja. Plucińska, et.al., Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, 34

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5607312

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spatial working memory_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0008428B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• neurodegeneration_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0002229B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• abnormal spatial reference memory_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0008414B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• decreased body weight_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0001262B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• abnormal nervous system morphology_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0003632B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• abnormal nervous system morphology_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0003632B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• neurodegeneration_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0002229B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• short stride length_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0001407B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• decreased body weight_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0001262B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• hypoactivity_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0001402B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• short stride length_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0001407B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• abnormal motor coordination/ balance_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0001516B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• hypoactivity_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0001402B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• decreased anxiety-related response_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0001364B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• impaired social transmission of food preference_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0002969B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• abnormal habituation to a new environment_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0011620B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• impaired social transmission of food preference_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0002969B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• neuronal intranuclear inclusions_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0004191B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• abnormal spatial working memory_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0008428B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• decreased anxiety-related response_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0001364B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• neuronal intranuclear inclusions_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0004191B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• abnormal motor coordination/ balance_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0001516B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• astrocytosis_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0003354B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno
• abnormal spatial reference memory_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0008414B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• astrocytosis_Hprt<tm5(Camk2a-BACE1)Geno>/Y
  http://metadb.riken.jp/0003354B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoYHprttm5Camk2aBACE1Geno
• abnormal habituation to a new environment_Hprt<tm5(Camk2a-BACE1)Geno>/Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/0011620B6129P2Hprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1GenoHprttm5Camk2aBACE1Geno

class

http://purl.org/net/cito/citesAsAuthority

• Hprt<tm5(Camk2a-BACE1)Geno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5607312