Jeffrey R. Gehlhausen, et.al., A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation., Human molecular genetics, 2015, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/25113746

Jeffrey R. Gehlhausen, et.al., A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation., Human molecular genetics, 2015, 24

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• head bobbing_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001410I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• trunk curl_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001512I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• impaired swimming_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001522I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• impaired righting response_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001523I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• enlarged dorsal root ganglion_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0008490I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• increased Schwann cell number_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0010742I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• head tilt_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0005191I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• increased neurofibrosarcoma incidence_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0002030I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• increased or absent threshold for auditory brainstem response_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0011967I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• increased Schwannoma incidence_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0010310I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• abnormal auditory brainstem response waveform shape_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0011966I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• abnormal spinal nerve morphology_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001077I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• head tossing_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0005307I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• sensorineural hearing loss_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0004740I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• circling_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001394I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc
• premature death_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0002083I129P2OlaHsdFVBNTacNf2tm2GthNf2tm2GthTgPostncre1Sjc0Nf2tm2GthTgPostncre1Sjc

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased Schwann cell number in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015210
• head tossing in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015207
• trunk curl in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015205
• sensorineural hearing loss in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015209
• enlarged dorsal root ganglion in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015211
• head bobbing in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015206
• impaired swimming in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015204
• abnormal auditory brainstem response waveform shape in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015208