Christin E. Burd, et.al., Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma., Cancer discovery, 2014, 4

http://rdf.ncbi.nlm.nih.gov/pubmed/25252692

Christin E. Burd, et.al., Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma., Cancer discovery, 2014, 4

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nras<tm1.1Nesh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5645358
• Nras<tm1Nesh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5645352

class

http://purl.org/net/cito/citesAsAuthority

• Nras<tm1.1Nesh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5645358
• Nras<tm1Nesh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5645352

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased cutaneous melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1Tyj>/Nras<tm1Tyj>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010322B6JCgNrastm1TyjCdkn2atm21NeshTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm1TyjNrastm1TyjTgTyrcreERT213Bos0Nrastm1TyjCdkn2atm21NeshTgTyrcreERT213Bos
• abnormal melanocyte proliferation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1Tyj>/Nras<tm1Tyj>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010741B6JCgNrastm1TyjCdkn2atm21NeshTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm1TyjNrastm1TyjTgTyrcreERT213Bos0Nrastm1TyjCdkn2atm21NeshTgTyrcreERT213Bos
• hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188B6JCgNrastm11NeshCdkn2atm21NeshTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm11NeshNrastm11NeshTgTyrcreERT213Bos0TgTyrcreERT213BosCdkn2atm21NeshNrastm11Nesh
• increased cutaneous melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010322B6JCgNrastm11NeshCdkn2atm21NeshTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm11NeshNrastm11NeshTgTyrcreERT213Bos0TgTyrcreERT213BosCdkn2atm21NeshNrastm11Nesh
• increased cutaneous melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010322B6JCgNrastm11NeshCdkn2atm21NeshStk11tm11RdpTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm11NeshNrastm11NeshStk11tm11RdpStk11tm11RdpTgTyrcreERT213Bos0TgTyrcreERT213BosCdkn2atm21NeshNrastm11NeshStk11tm11Rdp
• abnormal melanocyte proliferation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010741B6JCgNrastm11NeshCdkn2atm21NeshTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm11NeshNrastm11NeshTgTyrcreERT213Bos0TgTyrcreERT213BosCdkn2atm21NeshNrastm11Nesh
• hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1Tyj>/Nras<tm1Tyj>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188B6JCgNrastm1TyjCdkn2atm21NeshTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm1TyjNrastm1TyjTgTyrcreERT213Bos0Nrastm1TyjCdkn2atm21NeshTgTyrcreERT213Bos
• hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188B6JCgCdkn2atm21NeshKrastm4TyjTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTgTyrcreERT213Bos0KrasKrastm4TyjCdkn2atm21NeshTgTyrcreERT213Bos
• increased cutaneous melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010322B6JCgCdkn2atm21NeshKrastm4TyjTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTgTyrcreERT213Bos0KrasKrastm4TyjCdkn2atm21NeshTgTyrcreERT213Bos
• increased metastatic potential_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001272B6JCgNrastm11NeshCdkn2atm21NeshStk11tm11RdpTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm11NeshNrastm11NeshStk11tm11RdpStk11tm11RdpTgTyrcreERT213Bos0TgTyrcreERT213BosCdkn2atm21NeshNrastm11NeshStk11tm11Rdp