Mylène. Tajan, et.al., LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

http://rdf.ncbi.nlm.nih.gov/pubmed/25288766

Mylène. Tajan, et.al., LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1.1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5639081

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1.1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5639081

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• postnatal growth retardation_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0001732I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased circulating insulin level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0002727I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• slow postnatal weight gain_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0008489I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased circulating glucose level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0005560I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• abnormal heart septum morphology_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0006113I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased heart rate_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0005333I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• cardiac hypertrophy_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0001625I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• enhanced lipolysis_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0008034I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• thin ventricular wall_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0000280I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased systemic arterial blood pressure_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0002843I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased susceptibility to diet-induced obesity_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0005659I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased cardiac muscle contractility_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0005140I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• increased energy expenditure_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0004889I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• increased adipocyte glucose uptake_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0030016I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• dilated heart left ventricle_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0002753I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• ocular hypertelorism_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0001300I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• abnormal carbohydrate metabolism_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0013243I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• heart left ventricle hypertrophy_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0002625I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• abnormal epididymal fat pad morphology_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0006319I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased triglyceride level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0005318I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased brown adipose tissue amount_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0001780I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• improved glucose tolerance_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0005292I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• abnormal fat cell differentiation_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0011168I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• increased lean body mass_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0003960I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• enlarged spleen_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0000691I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• increased insulin sensitivity_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0002891I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased total body fat amount_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0010025I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• enlarged heart_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0000274I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• increased fat cell size_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0006094I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• increased glycerol level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0003441I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• abnormal lipid level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0001547I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased white fat cell number_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0009131I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased adiponectin level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0004893I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased subcutaneous adipose tissue amount_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0008844I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased circulating leptin level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0005668I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased cranium length_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0011862I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• dilated cardiomyopathy_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0002795I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• abnormal cranium size_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0010031I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased liver triglyceride level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0009356I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased circulating alanine transaminase level_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0002942I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11
• decreased cardiac stroke volume_Ptpn11<tm1.1Ics>/Ptpn11<+>
  http://metadb.riken.jp/0011952I129S2SvPasC57BL6FVBNPtpn11tm11IcsPtpn11Ptpn11tm11IcsPtpn11