Chantelle F. Sephton, et.al., Activity-dependent FUS dysregulation disrupts synaptic homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

http://rdf.ncbi.nlm.nih.gov/pubmed/25324524

Chantelle F. Sephton, et.al., Activity-dependent FUS dysregulation disrupts synaptic homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662097
• Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5644691
• Tg(CAG-lacZ,-FUS,-EGFP)629Gyu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5644690

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired righting response_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0001523I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• decreased body weight_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001262I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• decreased body weight_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0001262I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• hypoactivity_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001402I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• limb grasping_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001513I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• impaired righting response_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001523I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• premature death_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0002083I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• impaired coordination_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001405I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• abnormal neuromuscular synapse morphology_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001053I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• decreased grip strength_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0010053I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• abnormal dendrite morphology_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0008143I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• muscular atrophy_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0002269I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• abnormal neuromuscular synapse morphology_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0001053I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• muscular atrophy_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0002269I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• abnormal dendritic spine morphology_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0009936I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• microgliosis_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0008918I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• abnormal gait_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001406I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• limb grasping_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0001513I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• astrocytosis_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0003354I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• premature death_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0002083I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• abnormal motor capabilities/coordination/movement_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0002066I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• astrocytosis_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0003354I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• abnormal social investigation_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0001360I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• microgliosis_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0008918I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor
• decreased grip strength_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
  http://metadb.riken.jp/0010053I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSR521GEGFP682Gyu0Meox2tm1creSorTgCAGlacZFUSR521GEGFP682GyuMeox2
• abnormal gait_Meox2<tm1(cre)Sor>/Meox2<+>,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
  http://metadb.riken.jp/0001406I129S4SvJaeSorC57BL6Meox2tm1creSorMeox2TgCAGlacZFUSEGFP629Gyu0Meox2TgCAGlacZFUSEGFP629GyuMeox2tm1creSor

class

http://purl.org/net/cito/citesAsAuthority

• Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662097
• Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5644691
• Tg(CAG-lacZ,-FUS,-EGFP)629Gyu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5644690