Isabel. Hernández-Porras, et.al., K-RasV14I recapitulates Noonan syndrome in mice., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

http://rdf.ncbi.nlm.nih.gov/pubmed/25359213

Isabel. Hernández-Porras, et.al., K-RasV14I recapitulates Noonan syndrome in mice., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Kras<tm4Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5649293
• Kras<tm4.1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5649285

class

http://purl.org/net/cito/citesAsAuthority

• Kras<tm4Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5649293
• Kras<tm4.1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5649285

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal heart morphology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000266I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased leukocyte cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000218I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• enlarged spleen_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000691I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal common lymphocyte progenitor cell morphology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0008249I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• premature death_Kras<tm4.1Bbd>/Kras<+>
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrasKrasKrastm41Bbd
• thrombocytopenia_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0003179I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• anemia_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0001577I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased cranium height_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0011861I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal facial morphology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0003743I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• ocular hypertelorism_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0001300I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased cranium width_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000441I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal cranium morphology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000438I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• enlarged spleen_Kras<tm4.1Bbd>/Kras<+>
  http://metadb.riken.jp/0000691I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrasKrasKrastm41Bbd
• increased myocardial fiber number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0006321I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal kidney morphology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0002135I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• decreased cranium length_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0011862I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• heart hyperplasia_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000275I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal ear position_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000023I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal common myeloid progenitor cell morphology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0006410I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased basophil cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0002606I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• perinatal lethality, incomplete penetrance_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0011090129S2129CgKrastm41BbdKrastm41BbdKrastm41BbdKrastm41Bbd
• increased neutrophil cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000219I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased cardiac output_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0003394I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• decreased CD8-positive, alpha-beta T cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0008079I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal hematopoietic system morphology/development_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0002396I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal myocardial fiber physiology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0004215I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal snout morphology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000443I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• decreased body size_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0001265I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• perinatal lethality, incomplete penetrance_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0011090I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• extramedullary hematopoiesis_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000240I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• triangular face_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0012546I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• perinatal lethality, complete penetrance_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0011089B6J129FVBKrastm41BbdKrastm41BbdKrastm41BbdKrastm41Bbd
• abnormal bone marrow cell physiology_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0009278I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• premature death_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• decreased body length_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0001258I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased granulocyte monocyte progenitor cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0013696I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased cell proliferation_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000351I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased cardiac muscle contractility_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0005599I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• cellular necrosis_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0000316I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased myeloid cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0013663I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• thick aortic valve_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0010594I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased eosinophil cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0005011I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• slow postnatal weight gain_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0008489I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• spleen vascular congestion_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0010020I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd
• increased hematopoietic stem cell number_Kras<tm4.1Bbd>/Kras<tm4.1Bbd>
  http://metadb.riken.jp/0004809I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNKrastm41BbdKrastm41BbdKrastm41Bbd