Lore. Becker, et.al., MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy., PloS one, 2014, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/25506927

Lore. Becker, et.al., MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy., PloS one, 2014, 9

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired coordination_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0001405I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• abnormal response to novel object_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0003461I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• increased grip strength_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0010052I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• atrioventricular block_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0010519I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• increased physiological sensitivity to xenobiotic_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0008873I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• decreased QRS amplitude_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0010394I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• decreased heart rate_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0005333I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• ventricular premature beat_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0009732I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• prolonged QRS complex duration_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0010392I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• cardiomyopathy_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0005330I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• abnormal mitochondrial physiology_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0006036I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• decreased anxiety-related response_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0001364I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• decreased startle reflex_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0001489I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• dilated heart_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0004937I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• sinoatrial block_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0010520I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• dilated sarcoplasmic reticulum_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0004089I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• increased sensitivity to xenobiotic induced morbidity/mortality_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0009766I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• decreased mitochondrial DNA content_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0011639I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• hyperactivity_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0001399I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• myocardial fiber degeneration_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0004566I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• prolonged QT interval_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0003233I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• decreased body weight_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0001262I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• abnormal motor coordination/ balance_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0001516I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• increased heart weight_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0002833I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• irregular heartbeat_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0001636I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• abnormal mitochondrial inner membrane morphology_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0011634I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• cardiac muscle necrosis_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0010632I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst
• abnormal behavioral response to anesthetic_Mto1<Gt(G019A03)Wrst>/Mto1<Gt(G019A03)Wrst>
  http://metadb.riken.jp/0009777I129S2SvPasC57BL6JMto1GtG019A03WrstMto1GtG019A03WrstMto1GtG019A03Wrst