Natasa. Schiza, et.al., Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model., Human molecular genetics, 2015, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/25524707

Natasa. Schiza, et.al., Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model., Human molecular genetics, 2015, 24

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• axon degeneration_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0005405I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• abnormal oligodendrocyte morphology_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0000953I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• microgliosis_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0008918I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• demyelination_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0000921I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• astrocytosis_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0003354I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• tremors_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0000745I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• abnormal gait_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0001406I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• CNS inflammation_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0006082I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• dysmyelination_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0013438I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• dysmyelination_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0013438I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• abnormal oligodendrocyte morphology_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0000953I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• premature death_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• microgliosis_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0008918I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• abnormal oligodendrocyte apoptosis_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0010205I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• impaired coordination_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0001405I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• axon degeneration_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0005405I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• demyelination_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0000921I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• tonic seizures_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0002826I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• impaired coordination_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0001405I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• premature death_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• abnormal gait_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0001406I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• CNS inflammation_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0006082I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi
• tremors_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0000745I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• tonic seizures_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0002826I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• astrocytosis_Gjb1<tm1Kwi>/Y,Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>
  http://metadb.riken.jp/0003354I129P2OlaHsd129S4SvJaeC57BL6Gjb1tm1KwiYGjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjc2tm1EGFPKwi
• abnormal oligodendrocyte apoptosis_Gjc2<tm1(EGFP)Kwi>/Gjc2<tm1(EGFP)Kwi>,Gjb1<tm1Kwi>/Gjb1<tm1Kwi>
  http://metadb.riken.jp/0010205I129P2OlaHsd129S4SvJaeC57BL6Gjc2tm1EGFPKwiGjc2tm1EGFPKwiGjb1tm1KwiGjb1tm1KwiGjb1tm1KwiGjc2tm1EGFPKwi