Ronald L. Chandler, et.al., Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling., Nature communications, 2015, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/25625625

Ronald L. Chandler, et.al., Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling., Nature communications, 2015, 6

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Arid1a<tm1.1Mag>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5708705

class

http://purl.org/net/cito/citesAsAuthority

• Arid1a<tm1.1Mag>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5708705

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hemorrhagic ascites_Arid1a<tm1.1Mag>/Arid1a<tm1.1Mag>,Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0013184I129S6SvEvTacCD1Arid1atm11MagArid1atm11MagGtROSA26Sortm1Pik3caH1047REganGtROSA26SorArid1atm11MagGtROSA26SorGtROSA26Sortm1Pik3caH1047REgan
• increased interleukin-6 secretion_Arid1a<tm1.1Mag>/Arid1a<tm1.1Mag>,Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008705I129S6SvEvTacCD1Arid1atm11MagArid1atm11MagGtROSA26Sortm1Pik3caH1047REganGtROSA26SorArid1atm11MagGtROSA26SorGtROSA26Sortm1Pik3caH1047REgan
• abnormal ovary morphology_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001126I129S6SvEvTacCD1GtROSA26Sortm1Pik3caH1047REganGtROSA26SorGtROSA26SorGtROSA26Sortm1Pik3caH1047REgan
• increased metastatic potential_Arid1a<tm1.1Mag>/Arid1a<tm1.1Mag>,Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001272I129S6SvEvTacCD1Arid1atm11MagArid1atm11MagGtROSA26Sortm1Pik3caH1047REganGtROSA26SorArid1atm11MagGtROSA26SorGtROSA26Sortm1Pik3caH1047REgan
• increased ovarian carcinoma incidence_Arid1a<tm1.1Mag>/Arid1a<tm1.1Mag>,Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003579I129S6SvEvTacCD1Arid1atm11MagArid1atm11MagGtROSA26Sortm1Pik3caH1047REganGtROSA26SorArid1atm11MagGtROSA26SorGtROSA26Sortm1Pik3caH1047REgan
• abnormal ovary morphology_Arid1a<tm1.1Mag>/Arid1a<+>,Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001126I129S6SvEvTacCD1Arid1atm11MagArid1aGtROSA26Sortm1Pik3caH1047REganGtROSA26SorArid1aGtROSA26Sortm1Pik3caH1047REganGtROSA26SorArid1atm11Mag
• increased ovary tumor incidence_Arid1a<tm1.1Mag>/Arid1a<tm1.1Mag>,Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008000I129S6SvEvTacCD1Arid1atm11MagArid1atm11MagGtROSA26Sortm1Pik3caH1047REganGtROSA26SorArid1atm11MagGtROSA26SorGtROSA26Sortm1Pik3caH1047REgan