Lukas E. Dow, et.al., Inducible in vivo genome editing with CRISPR-Cas9., Nature biotechnology, 2015, 33

http://rdf.ncbi.nlm.nih.gov/pubmed/25690852

Lukas E. Dow, et.al., Inducible in vivo genome editing with CRISPR-Cas9., Nature biotechnology, 2015, 33

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm18(tetO-GFP,-cas9*)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755841
• Col1a1<tm20(tetO-GFP,-cas9*D10A)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755843
• Col1a1<tm17(tetO-GFP,-cas9*)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755839
• Col1a1<tm19(tetO-GFP,-cas9*)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755842

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• ectopic Paneth cells_Col1a1<tm19(tetO-GFP,-cas9*)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0014077I129S4SvJaeC57BL6Col1a1tm19tetOGFPcas9SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm19tetOGFPcas9Slowe
• abnormal small intestinal crypt cell proliferation_Col1a1<tm19(tetO-GFP,-cas9*)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010157I129S4SvJaeC57BL6Col1a1tm19tetOGFPcas9SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm19tetOGFPcas9Slowe
• ectopic Paneth cells_Col1a1<tm20(tetO-GFP,-cas9*D10A)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0014077I129S4SvJaeC57BL6Col1a1tm20tetOGFPcas9D10ASloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm20tetOGFPcas9D10ASloweGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal small intestinal crypt cell proliferation_Col1a1<tm17(tetO-GFP,-cas9*)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010157I129S4SvJaeC57BL6Col1a1tm17tetOGFPcas9SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm17tetOGFPcas9SloweGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26Sor
• abnormal small intestinal crypt cell physiology_Col1a1<tm19(tetO-GFP,-cas9*)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010156I129S4SvJaeC57BL6Col1a1tm19tetOGFPcas9SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm19tetOGFPcas9Slowe
• abnormal small intestinal crypt cell proliferation_Col1a1<tm20(tetO-GFP,-cas9*D10A)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010157I129S4SvJaeC57BL6Col1a1tm20tetOGFPcas9D10ASloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm20tetOGFPcas9D10ASloweGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• ectopic Paneth cells_Col1a1<tm17(tetO-GFP,-cas9*)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0014077I129S4SvJaeC57BL6Col1a1tm17tetOGFPcas9SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm17tetOGFPcas9SloweGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26Sor
• abnormal small intestinal crypt cell physiology_Col1a1<tm17(tetO-GFP,-cas9*)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010156I129S4SvJaeC57BL6Col1a1tm17tetOGFPcas9SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm17tetOGFPcas9SloweGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26Sor
• abnormal small intestinal crypt cell physiology_Col1a1<tm20(tetO-GFP,-cas9*D10A)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010156I129S4SvJaeC57BL6Col1a1tm20tetOGFPcas9D10ASloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm20tetOGFPcas9D10ASloweGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm18(tetO-GFP,-cas9*)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755841
• Col1a1<tm20(tetO-GFP,-cas9*D10A)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755843
• Col1a1<tm17(tetO-GFP,-cas9*)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755839
• Col1a1<tm19(tetO-GFP,-cas9*)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5755842