Ming-Shian. Tsai, et.al., Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development., Neurobiology of disease, 2015, 77

http://rdf.ncbi.nlm.nih.gov/pubmed/25725421

Ming-Shian. Tsai, et.al., Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development., Neurobiology of disease, 2015, 77

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Scn1a<tm1.1Swl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5699848

class

http://purl.org/net/cito/citesAsAuthority

• Scn1a<tm1.1Swl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5699848

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal dendrite morphology_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0008143I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• abnormal dendritic spine morphology_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0009936I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• abnormal miniature inhibitory postsynaptic currents_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0009435I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• postnatal lethality, complete penetrance_Scn1a<tm1.1Swl>/Scn1a<tm1.1Swl>
  http://metadb.riken.jp/0011085I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1atm11SwlScn1atm11Swl
• abnormal synaptic transmission_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0003635I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• abnormal gait_Scn1a<tm1.1Swl>/Scn1a<tm1.1Swl>
  http://metadb.riken.jp/0001406I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1atm11SwlScn1atm11Swl
• abnormal hippocampus granule cell morphology_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0009938I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• environmentally induced seizures_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0009358I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• abnormal miniature excitatory postsynaptic currents_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0004753I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• premature death_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl
• decreased body weight_Scn1a<tm1.1Swl>/Scn1a<tm1.1Swl>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1atm11SwlScn1atm11Swl
• premature death_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPasCrl129X1SvJScn1atm11SwlScn1aScn1aScn1atm11Swl
• tonic-clonic seizures_Scn1a<tm1.1Swl>/Scn1a<tm1.1Swl>
  http://metadb.riken.jp/0003997I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1atm11SwlScn1atm11Swl
• tonic-clonic seizures_Scn1a<tm1.1Swl>/Scn1a<+>
  http://metadb.riken.jp/0003997I129S1Sv129X1SvJC57BL6JNarlScn1atm11SwlScn1aScn1aScn1atm11Swl