Alberto. Martin, et.al., Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression., The EMBO journal, 2015, 34

http://rdf.ncbi.nlm.nih.gov/pubmed/25759215

Alberto. Martin, et.al., Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression., The EMBO journal, 2015, 34

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Loxl2<tm1.1Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750226
• Loxl2<tm1.2Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750228
• Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750303
• Gt(ROSA)26Sor<tm1(Loxl2)Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750301

class

http://purl.org/net/cito/citesAsAuthority

• Loxl2<tm1.1Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750226
• Loxl2<tm1.2Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750228
• Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750303
• Gt(ROSA)26Sor<tm1(Loxl2)Acan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5750301

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal seminiferous tubule morphology_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0002216NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• abnormal interventricular septum morphology_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0000281NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• testis degeneration_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0013600NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• lethality during fetal growth through weaning, incomplete penetrance_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0011112NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• male infertility_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0001925NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• decreased incidence of tumors by chemical induction_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0004502NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• epididymal inflammation_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0003596NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• spermatocele_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0014187NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• increased inflammatory response_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0001846NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• increased epididymal cell proliferation_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0014192NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• abnormal epididymis morphology_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0002631NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• decreased inflammatory response_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0001876NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• altered tumor pathology_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0010639NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• epididymis fibrosis_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0014188NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• abnormal liver vasculature morphology_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0009820NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• abnormal keratinocyte differentiation_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0002656NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• increased incidence of tumors by chemical induction_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0004499NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• decreased tumor growth/size_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0003447NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• altered tumor pathology_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0010639NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• abnormal keratinocyte differentiation_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0002656NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• decreased tumor latency_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0010308NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• cyanosis_Loxl2<tm1.2Acan>/Loxl2<tm1.2Acan>
  http://metadb.riken.jp/0001575NSLoxl2tm12AcanLoxl2tm12AcanLoxl2tm12Acan
• epididymis hypertrophy_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0014186NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• abnormal epididymis epithelium morphology_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0004933NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan
• increased epididymal epithelium cell proliferation_Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>/Gt(ROSA)26Sor<tm1.1(Loxl2)Acan>
  http://metadb.riken.jp/0014194NSGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2AcanGtROSA26Sortm11Loxl2Acan