Hye-Won. Song, et.al., shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects., PloS one, 2015, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/25790000

Hye-Won. Song, et.al., shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects., PloS one, 2015, 10

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(RNU6-RNAi:Rhox3)2Wilk
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763202
• Rhox<tm1Wilk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763216
• Rhox<tm1.1Wilk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763218

class

http://purl.org/net/cito/citesAsAuthority

• Tg(RNU6-RNAi:Rhox3)2Wilk
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763202
• Rhox<tm1Wilk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763216
• Rhox<tm1.1Wilk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763218

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased male germ cell apoptosis_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0014052IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• small seminiferous tubules_Rhox<tm1.1Wilk>/Rhox<tm1.1Wilk>
  http://metadb.riken.jp/0001153NSRhoxtm11WilkRhoxtm11WilkRhoxtm11Wilk
• decreased testis weight_Rhox<tm1Wilk>/Rhox<tm1Wilk>,Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0004852IFVBNJRhoxtm1WilkRhoxtm1WilkTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgStra8icre1RebRhoxtm1WilkTgRNU6RNAiRhox32Wilk
• small seminiferous tubules_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0001153IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• decreased male germ cell number_Rhox<tm1.1Wilk>/Rhox<tm1.1Wilk>
  http://metadb.riken.jp/0004901NSRhoxtm11WilkRhoxtm11WilkRhoxtm11Wilk
• abnormal male meiosis_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0005169IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• oligozoospermia_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0002687IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• abnormal spermatid morphology_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0006380IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• male infertility_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0001925IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• decreased male germ cell number_Rhox<tm1Wilk>/Rhox<tm1Wilk>,Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0004901IFVBNJRhoxtm1WilkRhoxtm1WilkTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgStra8icre1RebRhoxtm1WilkTgRNU6RNAiRhox32Wilk
• decreased male germ cell number_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0004901IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• oligozoospermia_Rhox<tm1Wilk>/Rhox<tm1Wilk>,Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0002687IFVBNJRhoxtm1WilkRhoxtm1WilkTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgStra8icre1RebRhoxtm1WilkTgRNU6RNAiRhox32Wilk
• small testis_Rhox<tm1.1Wilk>/Rhox<tm1.1Wilk>
  http://metadb.riken.jp/0001147NSRhoxtm11WilkRhoxtm11WilkRhoxtm11Wilk
• decreased testis weight_Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0004852IFVBNJTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgRNU6RNAiRhox32WilkTgStra8icre1Reb
• abnormal seminiferous tubule morphology_Rhox<tm1Wilk>/Rhox<tm1Wilk>,Tg(RNU6-RNAi:Rhox3)2Wilk/0,Tg(Stra8-icre)1Reb/0
  http://metadb.riken.jp/0002216IFVBNJRhoxtm1WilkRhoxtm1WilkTgRNU6RNAiRhox32Wilk0TgStra8icre1Reb0TgStra8icre1RebRhoxtm1WilkTgRNU6RNAiRhox32Wilk