Jessica L. Grieves, et.al., Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease., Proceedings of the National Academy of Sciences of the United States of America, 2015, 112

http://rdf.ncbi.nlm.nih.gov/pubmed/25848017

Jessica L. Grieves, et.al., Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease., Proceedings of the National Academy of Sciences of the United States of America, 2015, 112

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5751220

class

http://purl.org/net/cito/citesAsAuthority

• Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5751220

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal kidney morphology_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0002135I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• dilated heart ventricle_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0008022I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• atelectasis_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001177I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased susceptibility to systemic lupus erythematosus_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0004801I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• enlarged heart_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0000274I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• dilated heart atrium_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0003140I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• abnormal atrial thrombosis_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001855I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• lacrimal gland inflammation_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0008880I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• tubulointerstitial nephritis_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0011405I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• glomerulonephritis_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0002743I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• salivary gland inflammation_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001870I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• vasculitis_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001864I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• congestive heart failure_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0006138I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased regulatory T cell number_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0004973I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• pancreas inflammation_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001869I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased IgG level_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0002493I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• enlarged spleen_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0000691I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• lymphoid hyperplasia_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0000688I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased plasma cell number_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0008097I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• decreased litter size_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001935I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased CD4-positive, alpha beta T cell number_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0008074I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• lung inflammation_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001861I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• abnormal T cell activation_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001828I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased spleen weight_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0004952I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased CD4-positive, alpha beta T cell number_Trex1<tm1.1Fwpe>/Trex1<+>
  http://metadb.riken.jp/0008074I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1Trex1tm11FwpeTrex1
• abnormal immune system organ morphology_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0002722I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased inflammatory response_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001846I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• heart inflammation_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0001853I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased anti-double stranded DNA antibody level_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0004762I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• premature death_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0002083I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• enlarged lymph nodes_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0000702I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• liver vascular congestion_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0010019I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• abnormal heart morphology_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0000266I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased splenocyte number_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0009338I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe
• increased B cell number_Trex1<tm1.1Fwpe>/Trex1<tm1.1Fwpe>
  http://metadb.riken.jp/0005014I129S1SvImJ129S4SvJae129S6SvEvTacTrex1tm11FwpeTrex1tm11FwpeTrex1tm11Fwpe