Christopher T. Esapa, et.al., N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models., PloS one, 2015, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/25860694

Christopher T. Esapa, et.al., N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models., PloS one, 2015, 10

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Kl<ecalc1>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763757
• Kl<ecalc2>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763763

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired hearing_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0006325IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal zygomatic arch morphology_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0004469IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• decreased width of hypertrophic chondrocyte zone_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0003409IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• emphysema_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0001958IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• postnatal growth retardation_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0001732IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• abnormal femur morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0000559IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• short malleus_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0008373IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• increased vitamin D level_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0012337IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased body size_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0001265IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• short femur_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0003109IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• absent pinna reflex_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0006358IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased femur compact bone thickness_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0013624IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• lung inflammation_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0001861IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal skin morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0002060IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal femur morphology_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0000559IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• abnormal middle ear ossicle morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0005105IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• calcified aorta_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0010522IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• wide ribs_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0004676IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• postnatal growth retardation_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0001732IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased circulating serum albumin level_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0005419IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal malleus manubrium morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0008374IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• absent pinna reflex_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0006358IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• decreased circulating glucose level_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0005560IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• calcified skin_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0003196IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased bone mineral content_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0010124IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased bone mineral density_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0000063IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased femur compact bone thickness_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0013624IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• premature death_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0002083IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• calcified pulmonary alveolus_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0010923IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• premature death_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0002083IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• calcinosis_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0003195IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• calcinosis_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0003195IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• abnormal rib morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0000150IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• nephrocalcinosis_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0003197IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal malleus morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0000029IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• hunched posture_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0001505IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• impaired hearing_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0006325IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• abnormal long bone epiphyseal plate proliferative zone_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0003662IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal zygomatic arch morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0004469IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• kyphoscoliosis_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0000069IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• renal necrosis_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0003946IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal incus morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0005106IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• wide ribs_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0004676IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• short malleus manubrium_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0008375IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• hunched posture_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0001505IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal circulating protein level_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0005416IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal vertebrae morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0000137IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased long bone epiphyseal plate size_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0006396IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal stapes morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0005107IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• kyphoscoliosis_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0000069IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• increased circulating phosphate level_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0001566IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• short femur_Kl<ecalc2>/Kl<ecalc2>
  http://metadb.riken.jp/0003109IC3HHeHC57BL6JKlecalc2Klecalc2Klecalc2
• increased alkaline phosphatase activity_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0011584IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• thin epidermis_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0001218IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased subcutaneous adipose tissue amount_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0008844IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• abnormal aorta wall morphology_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0009866IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1
• decreased body size_Kl<ecalc1>/Kl<ecalc1>
  http://metadb.riken.jp/0001265IC3HHeHC57BL6JKlecalc1Klecalc1Klecalc1

class

http://purl.org/net/cito/citesAsAuthority

• Kl<ecalc1>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763757
• Kl<ecalc2>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5763763