Ariadna. Laguna, et.al., Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease., Nature neuroscience, 2015, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/25915474

Ariadna. Laguna, et.al., Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease., Nature neuroscience, 2015, 18

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired coordination_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0001405I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• neurodegeneration_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0002229I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• enhanced long term potentiation_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0003008I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• decreased dopamine level_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0005643I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• impaired olfaction_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0008544I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• abnormal lysosome physiology_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0003172I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• neurodegeneration_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Tg(Slc6a3-cre/ERT2)1Span/0
  http://metadb.riken.jp/0002229I129S7SvEvBrdC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcTgSlc6a3creERT21Span0TgSlc6a3creERT21SpanLmx1btm1ZfcLmx1atm1Tpe
• abnormal autophagy_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0008260I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• abnormal synaptic bouton morphology_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Tg(Slc6a3-cre/ERT2)1Span/0
  http://metadb.riken.jp/0008571I129S7SvEvBrdC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcTgSlc6a3creERT21Span0TgSlc6a3creERT21SpanLmx1btm1ZfcLmx1atm1Tpe
• abnormal synapse morphology_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0009538I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• abnormal short term object recognition memory_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0002800I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• abnormal synaptic bouton morphology_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0008571I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• hyperactivity_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0001399I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• decreased dopamine level_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Tg(Slc6a3-cre/ERT2)1Span/0
  http://metadb.riken.jp/0005643I129S7SvEvBrdC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcTgSlc6a3creERT21Span0TgSlc6a3creERT21SpanLmx1btm1ZfcLmx1atm1Tpe
• abnormal innervation_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0002184I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• abnormal synaptic vesicle number_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0004792I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc
• abnormal lysosome morphology_Lmx1a<tm1Tpe>/Lmx1a<tm1Tpe>,Lmx1b<tm1Zfc>/Lmx1b<tm1Zfc>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0005058I129S1Sv129S7SvEvBrd129X1SvJC57BL6Lmx1atm1TpeLmx1atm1TpeLmx1btm1ZfcLmx1btm1ZfcSlc6a3tm1creLrsnSlc6a3Slc6a3Lmx1atm1TpeSlc6a3tm1creLrsnLmx1btm1Zfc