Xue. Li, et.al., iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling., Proceedings of the National Academy of Sciences of the United States of America, 2015, 112

http://rdf.ncbi.nlm.nih.gov/pubmed/25918388

Xue. Li, et.al., iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling., Proceedings of the National Academy of Sciences of the United States of America, 2015, 112

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Rhbdf1<tm1b(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792831

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged aortic valve_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0010591I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• thick aortic valve cusps_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0010593I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• enlarged aortic valve_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0010591I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• thick pulmonary valve cusps_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0010605I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• decreased tumor necrosis factor secretion_Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0008561I129P2OlaHsdC57BL6Rhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1Mak
• abnormal leukocyte physiology_Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0002442I129P2OlaHsdC57BL6Rhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1Mak
• failure of eyelid fusion_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0009264I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• thick pulmonary valve cusps_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0010605I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• eyelids open at birth_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0001302I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• enlarged tricuspid valve_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0010627I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• perinatal lethality_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0002081I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• failure of eyelid fusion_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0009264I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• increased width of hypertrophic chondrocyte zone_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0003408I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• abnormal microglial cell physiology_Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0003691I129P2OlaHsdC57BL6Rhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1Mak
• perinatal lethality_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0002081I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• increased width of hypertrophic chondrocyte zone_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0003408I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• thick tricuspid valve cusps_Adam17<tm1.1Bbl>/Adam17<tm1.1Bbl>
  http://metadb.riken.jp/0010626I129P2OlaHsdC57BL6FVBNAdam17tm11BblAdam17tm11BblAdam17tm11Bbl
• eyelids open at birth_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0001302I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• thick aortic valve cusps_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0010593I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• thick tricuspid valve cusps_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0010626I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi
• enlarged pulmonary valve_Rhbdf1<tm1b(EUCOMM)Wtsi>/Rhbdf1<tm1b(EUCOMM)Wtsi>,Rhbdf2<tm1Mak>/Rhbdf2<tm1Mak>
  http://metadb.riken.jp/0010600I129P2OlaHsdC57BL6C57BL6NFVBNRhbdf1tm1bEUCOMMWtsiRhbdf1tm1bEUCOMMWtsiRhbdf2tm1MakRhbdf2tm1MakRhbdf2tm1MakRhbdf1tm1bEUCOMMWtsi

class

http://purl.org/net/cito/citesAsAuthority

• Rhbdf1<tm1b(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792831